EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

European Journal of Pharmaceutical and Medical Research (EJPMR) has indexed with various reputed international bodies like : Google Scholar , Indian Science Publications , InfoBase Index (In Process) , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , International Society for Research activity (ISRA) , Scientific Indexing Services (SIS) , Polish Scholarly Bibliography , Global Impact Factor (GIF) (Under Process) , Universal Impact Factor , International Scientific Indexing (ISI), UAE , Index Copernicus , CAS (A Division of American Chemical Society) USA (Under Process) , Directory of Open Access Journal (DOAJ, Sweden, in process) , UDLedge Science Citation Index , CiteFactor , Directory Of Research Journal Indexing (DRJI) , Indian citation Index (ICI) , Journal Index (JI, Under Process) , Directory of abstract indexing for Journals (DAIJ) , Open Access Journals (Under Process) , Impact Factor Services For International Journals (IFSIJ) , Cosmos Impact Factor , Jour Informatics (Under Process) , Eurasian Scientific Journal Index (ESJI) , International Innovative Journal Impact Factor (IIJIF) , Science Library Index, Dubai, United Arab Emirates , Pubmed Database [NLM ID: 101669306] (Under Process) , IP Indexing (IP Value 2.40) , Web of Science Group (Under Process) , Directory of Research Journals Indexing , Scholar Article Journal Index (SAJI) , International Scientific Indexing ( ISI ) , Scope Database , Academia ,

ISSN 2394-3211

Impact Factor: 7.065

ICV - 79.57

Abstract

HISTOPATHOLOGY ACTIVE BIPHENYL PYRROLE COMPOUND ISOLATED FROM MARINE BREVIBACTERIUM SPECIES

V. Srilekhaa, B. Prasanna*, A. Sridhar Rao, P. ShivaKrishna, V. Sheshasrinivas, M. A. Singaracharya*

ABSTRACT

A Biphenyl pyrrole (1) was identified in the marine Brevibacterium sp which was extracted from crude pigment and purified through RP-HPLC. Phylogenetic analysis based on 16S rRNA gene sequence comparison showed that the bacterium was closely related to the type strains of Brevibacterium species (99%). The bacterial strains which showed significant antimicrobial activity were identified to genus level by PCR amplification of the 16S rRNA gene, BLAST analysis, and comparison with sequences in the GenBank nucleotide database and the species level was identified as the nearest phylogenetic neighbor with sequences >99% sequence similarity. The Wound healing activity against Wistar Albino rats was also studied by using Safromycin ointment as standard drug. The complete structure of compound (1) was confirmed through IR, NMR and Mass spectral data.

Keywords: Brevibacterium sp, Marine bacteria, Biphenyl pyrrole, Wound healing, Wistar Albino.

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