EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

European Journal of Pharmaceutical and Medical Research (EJPMR) has indexed with various reputed international bodies like : Google Scholar , Indian Science Publications , InfoBase Index (In Process) , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , International Society for Research activity (ISRA) , Scientific Indexing Services (SIS) , Polish Scholarly Bibliography , Global Impact Factor (GIF) (Under Process) , Universal Impact Factor , International Scientific Indexing (ISI), UAE , Index Copernicus , CAS (A Division of American Chemical Society) USA (Under Process) , Directory of Open Access Journal (DOAJ, Sweden, in process) , UDLedge Science Citation Index , CiteFactor , Directory Of Research Journal Indexing (DRJI) , Indian citation Index (ICI) , Journal Index (JI, Under Process) , Directory of abstract indexing for Journals (DAIJ) , Open Access Journals (Under Process) , Impact Factor Services For International Journals (IFSIJ) , Cosmos Impact Factor , Jour Informatics (Under Process) , Eurasian Scientific Journal Index (ESJI) , International Innovative Journal Impact Factor (IIJIF) , Science Library Index, Dubai, United Arab Emirates , Pubmed Database [NLM ID: 101669306] (Under Process) , IP Indexing (IP Value 2.40) , Web of Science Group (Under Process) , Directory of Research Journals Indexing , Scholar Article Journal Index (SAJI) , International Scientific Indexing ( ISI ) , Scope Database , Academia ,

ISSN 2394-3211

Impact Factor: 7.065

ICV - 79.57

Abstract

APOPTOSIS: MOLECULAR MECHANISM AND TARGET IN CANCER THERAPY

Aneesa Fatima (BSc MLT)*, Neeru Bhaskar (MD Biochemisry), Rahul Kumar Mishr (MSc MLT Biochemistry), Shikhaa Mahajan (MD Biochemistry), Suvarna Prasad (MD Biochemistry), Nisha (MSc Medical Biochemistry)

ABSTRACT

Programmed cell death, or apoptosis has in the past two years undoubtly become more investigated biological process. Apoptosis is fundamentally distinct from other types of cell death based on its incidence, morphology and biochemistry. Particular morphological alterations of apoptotic cells include nuclear condensation and fragmentation, cell shrinkage, dynamic membrane blebbing, and loss of adhesion to extracellular matrices or to neighbors. Deeper understanding of the molecular mechanisms of apoptosis and its defective status opens the gate for a new class of targeted therapeutics.

Keywords: Apoptosis, Caspases, Cancer.

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