EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

European Journal of Pharmaceutical and Medical Research (EJPMR) has indexed with various reputed international bodies like : Google Scholar , Indian Science Publications , InfoBase Index (In Process) , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , International Society for Research activity (ISRA) , Scientific Indexing Services (SIS) , Polish Scholarly Bibliography , Global Impact Factor (GIF) (Under Process) , Universal Impact Factor , International Scientific Indexing (ISI), UAE  , Index Copernicus , CAS (A Division of American Chemical Society) USA (Under Process) , Directory of Open Access Journal (DOAJ, Sweden, in process) , UDLedge Science Citation Index , CiteFactor , Directory Of Research Journal Indexing (DRJI) , Indian citation Index (ICI) , Journal Index (JI, Under Process) , Directory of abstract indexing for Journals (DAIJ) , Open Access Journals (Under Process) , Impact Factor Services For International Journals (IFSIJ) , Cosmos Impact Factor , Jour Informatics (Under Process) , Eurasian Scientific Journal Index (ESJI) , International Innovative Journal Impact Factor (IIJIF) , Science Library Index, Dubai, United Arab Emirates , Pubmed Database [NLM ID: 101669306] (Under Process) , IP Indexing (IP Value 2.40) , Web of Science Group (Under Process) , Directory of Research Journals Indexing , Scholar Article Journal Index (SAJI) , International Scientific Indexing ( ISI ) , 

 ISSN 2394-3211

Impact Factor: 6.222

 ICV - 79.57

Abstract

FORMULATION, OPTIMIZATION AND INVITRO EVALUATION OF GASTRO RETENTIVE SUMATRIPTAN SUCCINATE TABLETS

G. Pratap Kumar*, Venkata Naga Swetha M. and T. Murali Krishna

ABSTRACT

The present work was aimed at developing effervescent floating tablets of Sumatriptan succinate using natural and synthetic polymers. Gas generating agents and diluent, glidant and lubricants are used in Sumatriptan succinate floating tablets with effervescent method were also formulated. Migraine is a common disorder characterized by a unilateral headache, which is often associated with nausea, vomiting, gastrointestinal disturbance and extreme sensitivity to light and sound. Sumatriptan succinate is the first member of a new class of anti-migraine compounds that act as a specific and selective 5-hydroxytryptamine-1 receptor agonist. Sumatriptan has low bioavailability after oral administration (about 15%), with a large inter-individual variation, although not affected by concomitant food intake. The dose is 50-100 mg orally. Tmax is reached at approximately 2 h and is slightly delayed by the presence of food and during an acute migraine attack. Sumatriptan succinate, an anti migraine agent, has been widely used for the treatment of anti migraine. It has been reported, however, that the duration of anti migranie action after a single oral dose of sumatriptan succinate is only 2-4 hr. Clinical use requires a dose of 50-100 mg to be taken onces a day but NMT 200mg/day. Sumatriptin succinate has a pH of 1.2 & remains stable at stomach environment. Frequency of dosing will be minimized. Objectives: 1. To increase patient compliance by preventing repetitive administration of the dosage forms. 2. To prolong drug release in a sustained manner using HPMC-K4M as the rate controlling polymer To increase the gastric residence time of Sodium bicarbonate by developing floating drug delivery systems. To evaluate the prepared dosage forms by carrying out suitable quality control tests.

Keywords: .


[Full Text Article]

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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing Scholar Article Journal Index (SAJI) International Scientific Indexing ( ISI )