ASSESSMENT OF THE ADMINISTRATION OF WATERMELON (CITRULLUS LANATUS) JUICE ON PLASMA POTASSIUM, SODIUM, CHLORIDE AND ZINC IN RABBITS OVERDOSED WITH ACETAMINOPHEN EXTRA
Mathew Folaranmi Olaniyan*, Lagundoye Sherifat Bolade and Olagundoye Serifat
Background: Watermelon juice has many non- scientific health beneficial claims due to its bioactive chemical constituents. Acetaminophen Extra contains paracetamol (500mg) and caffeine(65mg) used to relieve pain. Aim and Objective: This work was designed to evaluate the effect of watermelon juice in rabbits overdosed with acetaminophen extra using plasma zinc, potassium, chloride and sodium. Materials and Method: Thirty rabbits classified into six experimental groups labeled A-F (with C1, C2, E1 and E2) with A as control were investigated. An overdose of acetaminophen extra of 1,500mg/Kg was administered for 5 days into some of the rabbits to induce toxicity. 15ml/kg of watermelon juice was used to prevent and treat acetaminophen extra toxicity. Plasma potassium, zinc, chloride and sodium were analysed biochemically by spectrophotometry. Result: The result obtained showed that a significant reduction in plasma potassium and a significant increase in plasma sodium and chloride following the administration of 1500mg/Kg of acetaminophen extra for 5 days which was significantly normal after the administration of 15mg/Kg of watermelon juice (P<0.05). The result also showed a significant decrease in plasma zinc following the administration of acetaminophen extra overdose and watermelon juice. Conclusion: Abnormal plasma alterations in the concentration of Potassium, Sodium, Chloride and Zinc In rabbits overdosed with acetaminophen extra for 5 days was significantly reduced following the administration of 15ml/Kg BW.
Keywords: Watermelon juice has many non- scientific paracetamol (500mg) and caffeine(65mg) used to relieve pain.
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