EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

European Journal of Pharmaceutical and Medical Research (EJPMR) has indexed with various reputed international bodies like : Google Scholar , Indian Science Publications , InfoBase Index (In Process) , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , International Society for Research activity (ISRA) , Scientific Indexing Services (SIS) , Polish Scholarly Bibliography , Global Impact Factor (GIF) (Under Process) , Universal Impact Factor , International Scientific Indexing (ISI), UAE  , Index Copernicus , CAS (A Division of American Chemical Society) USA (Under Process) , Directory of Open Access Journal (DOAJ, Sweden, in process) , UDLedge Science Citation Index , CiteFactor , Directory Of Research Journal Indexing (DRJI) , Indian citation Index (ICI) , Journal Index (JI, Under Process) , Directory of abstract indexing for Journals (DAIJ) , Open Access Journals (Under Process) , Impact Factor Services For International Journals (IFSIJ) , Cosmos Impact Factor , Jour Informatics (Under Process) , Eurasian Scientific Journal Index (ESJI) , International Innovative Journal Impact Factor (IIJIF) , Science Library Index, Dubai, United Arab Emirates , Pubmed Database [NLM ID: 101669306] (Under Process) , IP Indexing (IP Value 2.40) , Web of Science Group (Under Process) , Directory of Research Journals Indexing , Scholar Article Journal Index (SAJI) , International Scientific Indexing ( ISI ) , 

 ISSN 2394-3211

Impact Factor: 6.222

 ICV - 79.57

Abstract

ASSESSMENT OF THE ADMINISTRATION OF WATERMELON (CITRULLUS LANATUS) JUICE ON PLASMA POTASSIUM, SODIUM, CHLORIDE AND ZINC IN RABBITS OVERDOSED WITH ACETAMINOPHEN EXTRA

Mathew Folaranmi Olaniyan*, Lagundoye Sherifat Bolade and Olagundoye Serifat

ABSTRACT

Background: Watermelon juice has many non- scientific health beneficial claims due to its bioactive chemical constituents. Acetaminophen Extra contains paracetamol (500mg) and caffeine(65mg) used to relieve pain. Aim and Objective: This work was designed to evaluate the effect of watermelon juice in rabbits overdosed with acetaminophen extra using plasma zinc, potassium, chloride and sodium. Materials and Method: Thirty rabbits classified into six experimental groups labeled A-F (with C1, C2, E1 and E2) with A as control were investigated. An overdose of acetaminophen extra of 1,500mg/Kg was administered for 5 days into some of the rabbits to induce toxicity. 15ml/kg of watermelon juice was used to prevent and treat acetaminophen extra toxicity. Plasma potassium, zinc, chloride and sodium were analysed biochemically by spectrophotometry. Result: The result obtained showed that a significant reduction in plasma potassium and a significant increase in plasma sodium and chloride following the administration of 1500mg/Kg of acetaminophen extra for 5 days which was significantly normal after the administration of 15mg/Kg of watermelon juice (P<0.05). The result also showed a significant decrease in plasma zinc following the administration of acetaminophen extra overdose and watermelon juice. Conclusion: Abnormal plasma alterations in the concentration of Potassium, Sodium, Chloride and Zinc In rabbits overdosed with acetaminophen extra for 5 days was significantly reduced following the administration of 15ml/Kg BW.

Keywords: Watermelon juice has many non- scientific paracetamol (500mg) and caffeine(65mg) used to relieve pain.


[Full Text Article]

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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing Scholar Article Journal Index (SAJI) International Scientific Indexing ( ISI )