EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

European Journal of Pharmaceutical and Medical Research (EJPMR) has indexed with various reputed international bodies like : Google Scholar , Indian Science Publications , InfoBase Index (In Process) , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , International Society for Research activity (ISRA) , Scientific Indexing Services (SIS) , Polish Scholarly Bibliography , Global Impact Factor (GIF) (Under Process) , Universal Impact Factor , International Scientific Indexing (ISI), UAE  , Index Copernicus , CAS (A Division of American Chemical Society) USA (Under Process) , Directory of Open Access Journal (DOAJ, Sweden, in process) , UDLedge Science Citation Index , CiteFactor , Directory Of Research Journal Indexing (DRJI) , Indian citation Index (ICI) , Journal Index (JI, Under Process) , Directory of abstract indexing for Journals (DAIJ) , Open Access Journals (Under Process) , Impact Factor Services For International Journals (IFSIJ) , Cosmos Impact Factor , Jour Informatics (Under Process) , Eurasian Scientific Journal Index (ESJI) , International Innovative Journal Impact Factor (IIJIF) , Science Library Index, Dubai, United Arab Emirates , Pubmed Database [NLM ID: 101669306] (Under Process) , IP Indexing (IP Value 2.40) , Web of Science Group (Under Process) , Directory of Research Journals Indexing , Scholar Article Journal Index (SAJI) , International Scientific Indexing ( ISI ) , 

 ISSN 2394-3211

Impact Factor: 6.222

 ICV - 79.57

Abstract

ANTI-INFLAMMATORY (IL-6, IL-10, IL-2 AND IL-4.) ACTIVITIES OF SOLANECIO BIAFRAE (WÒRÒWÓ) IN RABBITS INDUCED WITH INFLAMMATION OF THE LIVER USING ACETAMINOPHEN OVERDOSE

Mathew Folaranmi Olaniyan*

ABSTRACT

Background: Solanecio biafrae (Wòròwó) contains phytochemicals, specifically antioxidants such as vitamins with effective health benefits as it is evidenced in the use of the vegetable in traditional treatments. Acetaminophen is an anagelsic which people used irrationally that could lead to drug abuse and inflammation of the liver in overdoses or prolong administration, notwithstanding the normal therapeutic dose is safe. Materials and Methods: Fifteen rabbits of the same sex (male) with weight ranging from 1.0 -1.4 Kg were classified into control (n=5) given water and normal meal alone through out the period of investigation and experimental groups such as B1 (n=5) ; B2; were the B1 rabbits that were given 400mg/kgBW supplement of ethanolic extract of Solanecio biafrae (Wòròwó) after acetaminophen overdose for 7 days; C1(n=5) these were rabbits given 2,500mg/kgBW of acetaminophen before the aqueous extract of Solanecio biafrae (Wòròwó) while C2; were the C1 rabbits that were given 400mg/kgBW supplement of aqueous extract of Solanecio biafrae (Wòròwó) after acetaminophen overdose for 7 days. Plasma Aspartate Transaminase (AST/SGOT) and Alanine Transaminase (ALT/SGPT) were measured by spectrophotometry while the Interleukins 2, 4, 6 and 10(IL-2, IL-4, IL-6 and IL-10)were determined in the plasma of the rabbits by ELISA. Results: There was a significantly higher mean plasma values of AST, ALT, IL-2, IL-4, IL-6 and IL-10 in rabbits given 2,500mg/kgMW of acetaminophen than in control rabbits and then when these rabbits were given the supplements of ethanolic and aqueous extract of Solanecio biafrae (Wòròwó) following the administration of 2,500mg/kgMW of acetaminophen(p<0.05). Conclusion: There was an increase in plasma AST, ALT, IL-2, IL-4, IL-6 and IL-10 after a 7 day overdose of acetaminophen due to possible drug induced hepatotoxicity, inflammation and liver damage which was significantly reduced when the rabbits were given the ethanolic and aqueous extracts Solanecio biafrae (Wòròwó). Consequently, the extract could be a good supplement at reducing drug-induced hepatotoxicity/hepatitis.

Keywords: Solanecio biafrae.


[Full Text Article]

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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing Scholar Article Journal Index (SAJI) International Scientific Indexing ( ISI )