EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

European Journal of Pharmaceutical and Medical Research (EJPMR) has indexed with various reputed international bodies like : Google Scholar , Indian Science Publications , InfoBase Index (In Process) , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , International Society for Research activity (ISRA) , Scientific Indexing Services (SIS) , Polish Scholarly Bibliography , Global Impact Factor (GIF) (Under Process) , Universal Impact Factor , International Scientific Indexing (ISI), UAE  , Index Copernicus , CAS (A Division of American Chemical Society) USA (Under Process) , Directory of Open Access Journal (DOAJ, Sweden, in process) , UDLedge Science Citation Index , CiteFactor , Directory Of Research Journal Indexing (DRJI) , Indian citation Index (ICI) , Journal Index (JI, Under Process) , Directory of abstract indexing for Journals (DAIJ) , Open Access Journals (Under Process) , Impact Factor Services For International Journals (IFSIJ) , Cosmos Impact Factor , Jour Informatics (Under Process) , Eurasian Scientific Journal Index (ESJI) , International Innovative Journal Impact Factor (IIJIF) , Science Library Index, Dubai, United Arab Emirates , Pubmed Database [NLM ID: 101669306] (Under Process) , IP Indexing (IP Value 2.40) , Web of Science Group (Under Process) , Directory of Research Journals Indexing , Scholar Article Journal Index (SAJI) , International Scientific Indexing ( ISI ) , Scope Database , Academia , 

 ISSN 2394-3211

Impact Factor: 7.065

 ICV - 79.57

Abstract

FETAL HEPATORENAL TOXICITY OF ARTEMETHER/LUMEFANTRINE (COARTEM®) IN SECOND TRIMESTER OF PREGNANCY IN ALBINO RATS

*Umoh I. U., Ekanem T. B., Eluwa M. A. and Bassey U. E.

ABSTRACT

The effect of artemether/lumefantrine (Coartem®) administration in second trimester of pregnancy on the morphometric indices of rat fetuses, fetal liver and kidney as well as amniotic alpha fetoprotein was investigated in this study. Twenty (20) pregnant albino Wistar rats were divided into 4 groups of 5 animals per group and used for the study. Group 1 served as control and received no drug treatment. Group 2 received 8mg/kg (therapeutic dose) of coartem while Groups 3 and 4 received 16mg/kg and 24mg/kg of coartem respectively. The drug was administered twice daily for three days being its normal therapeutic regimen. The animals were sacrificed on the 20th day of pregnancy under chloroform anaesthesia, fetuses delivered through uterotomy and assessed for morphological deformities. Fetal liver and kidney were harvested and evaluated for histopathology. Amniotic fluid was obtained and used to assay for alpha fetoprotein (AFP) levels. A significant (P < 0.05) dose dependent decrease in fetal body weight, crown rump length was observed in the fetuses of the treated groups when compared to the control. Significant decrease in amniotic alpha fetoprotein was also observed in Group 2 and 4 while the AFP level in Group 3 was significantly increased (P < 0.05). The histology of fetal liver revealed mild to severe alterations in cellular cytoarchitecture and features such as hepatocytic necrosis, dilated central veins and sinusoidal spaces were observed in the treatment groups. Sections of the fetal kidney showed atrophic and degenerated glomeruli as well as tubular necrosis whose severity increased with increasing dose of coartem. The study has shown that artemether/lumefantrine is toxic to fetal liver and kidney when administered to pregnant albino wistar rats in second trimester and fetal growth was also reduced significantly.

Keywords: Artemether/Lumefantrine, Coartem, Fetal hepatorenal toxicity, pregnancy.


[Full Text Article] [Download Certificate]

Citation

  All Since 2019
 Citation  3086  2560
 h-index  18  17
 i10-index  64  44

INDEXING

NEWS & UPDATION

  • EJPMR New Impact Factor

    EJPMR Impact Factor has been Increased to 7.065 for Year 2024.

  • EJPMR: FEBRUARY ISSUE PUBLISHED

    FEBRUARY 2024 issue has been successfully launched on 1 FEBRUARY 2024.

  • New Issue Published

    Its Our pleasure to inform you that, EJPMR 1 February 2024 Issue has been Published, Kindly check it on https://www.ejpmr.com/issue

  • Index Copernicus Value

    EJPMR Received Index Copernicus Value 79.57, due to High Quality Publication in EJPMR at International Level

  • Journal web site support Internet Explorer, Google Chrome, Mozilla Firefox, Opera, Saffari for easy download of article without any trouble.

    .

  • Article Invited for Publication

    Article are invited for publication in EJPMR Coming Issue

Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing Scholar Article Journal Index (SAJI) International Scientific Indexing ( ISI ) Scope Database Academia