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An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

European Journal of Pharmaceutical and Medical Research (EJPMR) has indexed with various reputed international bodies like : Google Scholar , Indian Science Publications , InfoBase Index (In Process) , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , International Society for Research activity (ISRA) , Scientific Indexing Services (SIS) , Polish Scholarly Bibliography , Global Impact Factor (GIF) (Under Process) , Universal Impact Factor , International Scientific Indexing (ISI), UAE  , Index Copernicus , CAS (A Division of American Chemical Society) USA (Under Process) , Directory of Open Access Journal (DOAJ, Sweden, in process) , UDLedge Science Citation Index , CiteFactor , Directory Of Research Journal Indexing (DRJI) , Indian citation Index (ICI) , Journal Index (JI, Under Process) , Directory of abstract indexing for Journals (DAIJ) , Open Access Journals (Under Process) , Impact Factor Services For International Journals (IFSIJ) , Cosmos Impact Factor , Jour Informatics (Under Process) , Eurasian Scientific Journal Index (ESJI) , International Innovative Journal Impact Factor (IIJIF) , Science Library Index, Dubai, United Arab Emirates , Pubmed Database [NLM ID: 101669306] (Under Process) , IP Indexing (IP Value 2.40) , Web of Science Group (Under Process) , Directory of Research Journals Indexing , Scholar Article Journal Index (SAJI) , International Scientific Indexing ( ISI ) , Scope Database , Academia , 

 ISSN 2394-3211

Impact Factor: 7.065

 ICV - 79.57



*Umoh I. U., Ekanem T. B., Eluwa M. A. and Bassey U. E.


The effect of artemether/lumefantrine (Coartem®) administration in second trimester of pregnancy on the morphometric indices of rat fetuses, fetal liver and kidney as well as amniotic alpha fetoprotein was investigated in this study. Twenty (20) pregnant albino Wistar rats were divided into 4 groups of 5 animals per group and used for the study. Group 1 served as control and received no drug treatment. Group 2 received 8mg/kg (therapeutic dose) of coartem while Groups 3 and 4 received 16mg/kg and 24mg/kg of coartem respectively. The drug was administered twice daily for three days being its normal therapeutic regimen. The animals were sacrificed on the 20th day of pregnancy under chloroform anaesthesia, fetuses delivered through uterotomy and assessed for morphological deformities. Fetal liver and kidney were harvested and evaluated for histopathology. Amniotic fluid was obtained and used to assay for alpha fetoprotein (AFP) levels. A significant (P < 0.05) dose dependent decrease in fetal body weight, crown rump length was observed in the fetuses of the treated groups when compared to the control. Significant decrease in amniotic alpha fetoprotein was also observed in Group 2 and 4 while the AFP level in Group 3 was significantly increased (P < 0.05). The histology of fetal liver revealed mild to severe alterations in cellular cytoarchitecture and features such as hepatocytic necrosis, dilated central veins and sinusoidal spaces were observed in the treatment groups. Sections of the fetal kidney showed atrophic and degenerated glomeruli as well as tubular necrosis whose severity increased with increasing dose of coartem. The study has shown that artemether/lumefantrine is toxic to fetal liver and kidney when administered to pregnant albino wistar rats in second trimester and fetal growth was also reduced significantly.

Keywords: Artemether/Lumefantrine, Coartem, Fetal hepatorenal toxicity, pregnancy.

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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing Scholar Article Journal Index (SAJI) International Scientific Indexing ( ISI ) Scope Database Academia