FORMULATION AND EVALUATION OF ETOFIBRATE SELF-EMULSIFYING DRUG DELIVERY SYSTEM (SEDDS)

Xiao-Fei Li, Xiao-Ping Liu and K. P. Rakesh*

ABSTRACT

Aim: The aim of the current study is to develop self-emulsifying drug delivery systems (SEDDS) of etofibrate to enhance the dissolution of poorly soluble etofibrate. Methods: The pseudo-ternary phase diagram was constructed to find the optimised formulation. The characterization of the selected formulations were evaluated including the droplet size after dispersion, zeta potential, drug content and in vitro dissolution. Results: The SEDDS were developed using oleic acid, Tween-80 and isopropanol as oil, surfactant and co-surfactant respectively. The dissolution test demonstrated that nearly 90% of etofibrate were dissolved from SEDDS within 60 min while only about 15% of raw drug were dissolved in 60 min. Further, the stability studies for 6 months revealed that SEDDS of etofibrate are found to be stable without any significant change in physicochemical properties. Conclusion: The prepared SEDDS enhance the dissolution of poorly soluble drug and has a potential to enhance drug absorption and improve bioavailability of drug.3

Keywords: Etofibrate, SEDDS, Pseudo-ternary phase diagram, Dissolution.