( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

European Journal of Pharmaceutical and Medical Research (EJPMR) has indexed with various reputed international bodies like : Google Scholar , Indian Science Publications , InfoBase Index (In Process) , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , International Society for Research activity (ISRA) , Scientific Indexing Services (SIS) , Polish Scholarly Bibliography , Global Impact Factor (GIF) (Under Process) , Universal Impact Factor , International Scientific Indexing (ISI), UAE  , Index Copernicus , CAS (A Division of American Chemical Society) USA (Under Process) , Directory of Open Access Journal (DOAJ, Sweden, in process) , UDLedge Science Citation Index , CiteFactor , Directory Of Research Journal Indexing (DRJI) , Indian citation Index (ICI) , Journal Index (JI, Under Process) , Directory of abstract indexing for Journals (DAIJ) , Open Access Journals (Under Process) , Impact Factor Services For International Journals (IFSIJ) , Cosmos Impact Factor , Jour Informatics (Under Process) , Eurasian Scientific Journal Index (ESJI) , International Innovative Journal Impact Factor (IIJIF) , Science Library Index, Dubai, United Arab Emirates , Pubmed Database [NLM ID: 101669306] (Under Process) , IP Indexing (IP Value 2.40) , Web of Science Group (Under Process) , Directory of Research Journals Indexing , Scholar Article Journal Index (SAJI) , International Scientific Indexing ( ISI ) , Scope Database , Academia , 

 ISSN 2394-3211

Impact Factor: 7.065

 ICV - 79.57



Esmat Zien El-Deen, Ahmed Donia and Rasha Zidan*


The present study was undertaken to develop and evaluate controlled release formulations of Losartan potassium by using different polymers in various drug to polymer ratios [1:1, 1:2 &1:3]. Polymers used were Eudragit RS100, Eudragit L100, Eudragit S100, Ethyl cellulose and Hydroxypropylmethylcellulose (HPMC). Fourier Transform Infrared spectroscopy (FT-IR) as well as Differential Scanning Calorimetry (DSC) studies revealed no chemical interaction between the drug and polymer used. The micromeritic properties of the prepared formulations proved that by increasing the ratio of the polymer in the blend, it was followed by decreasing the angle of repose (from 40.20 0 of the plain drug to 29 0), Carr,s index (from 31.40% of the plain drug to 9% ), Hausner ratio (from 1.46 of the plain drug to 1.02). Drug release from the prepared formulations was followed at three pH values [1.0, 6.8 &7.4] representing the main segments of G I T. It was revealed that by increasing the concentration of the polymer in the blend a retarding effect of the drug release was observed in the orded 1:3> 1:2>1:1. Mixing the plain drug with solid dispersion system of Eudragit L100 (that offers drug release at pH6.8) and solid dispersion system of Eudragit S100 (that offers drug release at pH7.4) in a physical mixture offers both immediate and controlled release thus increase the patient compliance.

Keywords: Losartan potassium, solid dispersions, controlled release.

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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing Scholar Article Journal Index (SAJI) International Scientific Indexing ( ISI ) Scope Database Academia