EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

European Journal of Pharmaceutical and Medical Research (EJPMR) has indexed with various reputed international bodies like : Google Scholar , Indian Science Publications , InfoBase Index (In Process) , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , International Society for Research activity (ISRA) , Scientific Indexing Services (SIS) , Polish Scholarly Bibliography , Global Impact Factor (GIF) (Under Process) , Universal Impact Factor , International Scientific Indexing (ISI), UAE  , Index Copernicus , CAS (A Division of American Chemical Society) USA (Under Process) , Directory of Open Access Journal (DOAJ, Sweden, in process) , UDLedge Science Citation Index , CiteFactor , Directory Of Research Journal Indexing (DRJI) , Indian citation Index (ICI) , Journal Index (JI, Under Process) , Directory of abstract indexing for Journals (DAIJ) , Open Access Journals (Under Process) , Impact Factor Services For International Journals (IFSIJ) , Cosmos Impact Factor , Jour Informatics (Under Process) , Eurasian Scientific Journal Index (ESJI) , International Innovative Journal Impact Factor (IIJIF) , Science Library Index, Dubai, United Arab Emirates , Pubmed Database [NLM ID: 101669306] (Under Process) , IP Indexing (IP Value 2.40) , Web of Science Group (Under Process) , Directory of Research Journals Indexing , Scholar Article Journal Index (SAJI) , International Scientific Indexing ( ISI ) , 

 ISSN 2394-3211

Impact Factor: 6.222

 ICV - 79.57

Abstract

IN VITRO ANTIOXIDANT ACTIVITY AND IN VIVO ANALGESIC, CYTOTOXIC AND CENTRAL NERVOUS SYSTEM DEPRESSION EFFECTS OF ETHANOLIC EXTRACT OF LEUCAS ZEYLANICA (L.) W.T. AITON IN SWISS ALBINO MICE

Md. Mohsin Mian*, Fahmida Fyza Redi and Abdur Rahman

ABSTRACT

Aim: Leucas zeylanica (L.) W. T. Aiton can be traced through the medicinal history as a safe ethno medicinal herb and has been put to treat headache, abdominal pain, and convulsion in India, Bangladesh and China in folkloric medicine. The aim of the study was to evaluate CNS depression, cytotoxic, analgesic and antioxidant activities of whole plant extract of L. zeylanica to justify the traditional uses as per scientific basis. Methods: CNS depressant activity of ethanolic extract was evaluated by hole cross test at dose of 100 and 200 mg/kg. Analgesic activity was determined by acetic acid-induced writhing and formalin-induced paw licking and biting test at 150 and 300mg/kg dose and cytotoxicity and antioxidant activity was assessed by Brine shrimp lethality bioassay and DPPH (1, 1-diphenyl-2-picrylhydrazyl) free radical scavenging assay respectively. The analysis was conducted at the end of 2015. Result: The extract of L. zeylanica showed a significant dose dependent CNS depressant action by lowering the movement of mice mostly at 60 and 120 minute. The extract also possessed 60.73% (P< 0.01) and 81.94% (P<0.01) inhibition in acetic acid induced writhing test and formalin induced paw licking and biting test. Cytotoxicity screening illustrated moderate to potent toxicity to Artemia salina with LC50 value 11.063μg/ml. Non-enzymatic antioxidant effect was exhibited in a concentration-dependent manner. Conclusion: The study demonstrated analgesic, cytotoxic, central nervous system depression and antioxidant effect of L. zeylanica plant.

Keywords: Analgesic study, CNS activity, antioxidant potential, cytotoxicity, Leucas zeylanica.


[Full Text Article]

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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing Scholar Article Journal Index (SAJI) International Scientific Indexing ( ISI )