EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

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 ISSN 2394-3211

Impact Factor: 7.065

 ICV - 79.57

Abstract

GAMMA GLUTAMYL TRANSFERASE AS A PREDICTIVE MARKER OF MICROALBUMINURIA IN DIABETIC NEPHROPATHY

*Dr. Muhammad Haroon Mujtaba Memon MBBS, Dr. Waqas Memon MBBS, Dr. Shahzeem Shoukat Memon MBBS, Dr. Ramsha Fazal MBBS and Dr. Abeer Rafique MBBS, FCPS

ABSTRACT

Objective: To determine predictive value of gamma glutamyl transferase (ϒ-GT) for microalbuminuria in diabetic nephropathy. Study Design: Case control study. Place & Duration: Department of Medicine –Jinnah Post Graduate Medical Center, Karachi from December 2015- August 2016. Subjects & Methods: 45 healthy controls and 55 type 2 diabetics were selected through non-probability purposive sampling. Microalbuminuria can be diagnosed from a 24-hour urine collection. BUN, serum creatinine, albumin, bilirubin, uric acid, blood glucose, HbA1c, serum creatinine and blood lipids were analyzed. Urinary albumin was estimated by immunoturbidometry method and ϒ-GT by IFCC method. Data was analyzed by statistical package SPSS 22.0 and Graph Pad Prism. Results: Albuminuria and ϒ-GT in controls and cases were found as 19.73±5.21 and 150.47± 102.43 mg/dL and 21.62±5.36 and 36.27± 6.33 U/L (P=0.001) respectively. ϒ-GT showed positive correlation with Microalbuminura (r= 0.871, P=0.0001). ϒ-GT, on linear regression model, predicted the microalbuminuria, F= 221.82, P= 00001, R2 = 0.694. In binary logistic regression analysis, ϒ-GT was strongly predicted the microalbuminuria (AUC=0.914, Odd ratio= 1.366, P = 0.0001). Conclusion: The ϒ-GT may be used as alternative screening test for predicting the microalbuminuria in type 2 diabetics. ϒ-GT levels along with urinary albumin may help in early detection of diabetic nephropathy.

Keywords: ?-Glutamyl transferase Microalbuminuria Diabetic nephropathy.


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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing Scholar Article Journal Index (SAJI) International Scientific Indexing ( ISI ) Scope Database Academia