EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

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 ISSN 2394-3211

Impact Factor: 7.065

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Abstract

PREVALENCE OF HEPATITIS C VIRUS AMONG PREGNANT WOMEN OF UPPER EGYPT

Mahmoud Edessy, Mahmoud I. El-Rasheedy, Abd El-Naser Abd El-Gaber Ali#, Salim Ahmed, Ahmad Hashim, Ahmed Ali M. Nasr* and Emad Farouk##

ABSTRACT

Background: Egypt is a hepatitis C anomaly. Roughly 1: 50 persons are infected with hepatitis C virus (HCV), nearly one person in ten carries viral RNA and is therefore chronically infected (1). Objective: to find out the prevalence of HCV infection among pregnant women and the possibility of vertical transmission to newborns. Patients & Methds: A total of 1036 full term pregnant women were randomly selected from those attendants of delivery ward of obstetrics department in hospitals of three governorates of Upper Egypt (Assiut, South Vally and Luxor) from September 2014 to December 2015. 3-4 ml of venous blood were obtained from all participants and 5ml of Cord blood immediately after birth in delivery ward or operative room from all babies whom their mother had positive HCV-RNA test. HCV detected by Acon cards (HCV antibody using a third-generation ELISA kit), Positive samples were submitted to a confirmatory test using RNA polymerase chain reaction (bioelisa HCV 4.0). Results: Out of 1036 pregnant women, HCV antibodies test was positive in only 55 cases (5.31%) and was negative in 981 cases (94.69%). According to PCR assay, patients were classified into two groups (Group I with PCR positive in 36 cases (3.4%) and Group II with negative PCR in 1000 cases (96.6%)). As regard to vertical transmission, 19 infants (52.8%) had HCV antibodies positive test but 4 infants only (11.1%) had HCV-PCR positive. Risk factors for HCV infection were advanced maternal age, history of blood transfusion, history of previous surgery, positive husband HCV infection, working at health services (p value <0.001) and residence in rural areas (p value <0.01). Conclusions: The prevalence of HCV in pregnant women in Upper Egypt is lower than in Delta Egypt and had same incidence in other countries. Risk factors for transmission are age, parity, past history of previous surgery, blood transfusion, husbands with HCV infection, working at health services and in rural areas.

Keywords: HCV- Pregnant women - Upper Egypt.


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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing Scholar Article Journal Index (SAJI) International Scientific Indexing ( ISI ) Scope Database Academia