STUDY OF EFFECT OF PLANT DERIVED ANTIOXIDANTS FLAVONOIDS IN CAD PATIENTS

*R. Vasudeva

ABSTRACT

Developing societies are faced with a hostile cardiovascular environment, leading to an increasing epidemic of cardiovascular disease. This has placed a large socio economic burden on countries like India. The present study attempts to explore the role of plant derived antioxidants in reducing the oxidative stress which is largely the cause of CAD. Terminalia arjuna is an ancient cardiovascular drug. Its bark extract has significant inotropic and hypolipidemic properties. CAD patients taken from wards of government hospital were administered the extract along with conventional treatment and the effect on ST segment depression in ECG was noted at baseline and 3 monthly follow-up. Electrocardiographic improvement was seen to be highly significant. These results reveal the antiatherogenic potential of flavonoids present in Terminalia bark extract. Antioxidants, coronary artery disease, oxidative stress, Terminalia arjuna.

Keywords: Antioxidants, coronary artery disease, oxidative stress, Terminalia arjuna.