EXPERIMENTAL EVALUATION OF ANTI-DIABETIC ACTIVITY AND ANTI HYPERLIPIDEMIC EVALUATION OF LEAF EXTRACTS OF SENNA ALATA IN ALLOXAN INDUCED DIABETIC RATS
Rama Swamy Nanna*, Archana Pamulaparthi, Vamshi Ramana Prathap, Mahitha Banala
Senna alata (Syn. Cassia alata) is an ethnomedicinal plant belonging
to the family Fabaceae. A number of bioactive constituents which
contribute to the medicinal properties are attributed to the species. The
present study is aimed to evaluate the anti diabetic activity attributed to
the species and also to evaluate the anti hyperlipidemic potential of the
species using various standard experimental models available. Acute
toxicity studies of aqueous leaf extracts of S. alata were performed
upto a dose of 2500mg/kg bodyweight of rats and a dose of 200 mg/kg
was selected for the present study. Aqueous leaf extracts of
S. alata showed a significant (P<0.01) anti diabetic and anti hyperlipedimic potential in
alloxan induced diabetic rats within 15 days of induction of diabetes and the antidiabetic
potential of the species may be due to the presence of flavonoids.
Keywords: Senna alata, Alloxan induced diabetes, Anti Diabetic, Anti Hyperlipedemic.
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