EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

European Journal of Pharmaceutical and Medical Research (EJPMR) has indexed with various reputed international bodies like : Google Scholar , Indian Science Publications , InfoBase Index (In Process) , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , International Society for Research activity (ISRA) , Scientific Indexing Services (SIS) , Polish Scholarly Bibliography , Global Impact Factor (GIF) (Under Process) , Universal Impact Factor , International Scientific Indexing (ISI), UAE  , Index Copernicus , CAS (A Division of American Chemical Society) USA (Under Process) , Directory of Open Access Journal (DOAJ, Sweden, in process) , UDLedge Science Citation Index , CiteFactor , Directory Of Research Journal Indexing (DRJI) , Indian citation Index (ICI) , Journal Index (JI, Under Process) , Directory of abstract indexing for Journals (DAIJ) , Open Access Journals (Under Process) , Impact Factor Services For International Journals (IFSIJ) , Cosmos Impact Factor , Jour Informatics (Under Process) , Eurasian Scientific Journal Index (ESJI) , International Innovative Journal Impact Factor (IIJIF) , Science Library Index, Dubai, United Arab Emirates , Pubmed Database [NLM ID: 101669306] (Under Process) , IP Indexing (IP Value 2.40) , Web of Science Group (Under Process) , Directory of Research Journals Indexing , Scholar Article Journal Index (SAJI) , International Scientific Indexing ( ISI ) , 

 ISSN 2394-3211

Impact Factor: 6.222

 ICV - 79.57

Abstract

THE EFFECT OF ANTICOAGULANTS, STORAGE TIME AND TEMPERATURE ON LIPOPROTEIN CONCENTRATIONS OF APPARENTLY HEALTHY SUBJECTS IN PORT HARCOURT, NIGERIA.

Ebirien-Agana Samuel Bartimaeus*, Stella Urekweru Ken-Ezihuo and Theodora Onyema Austin

ABSTRACT

Background: This study was designed to investigate the effect of anticoagulants (lithium heparin and fluoride oxalate) on lipoprotein levels obtained from samples which were analyzed within 2h after collection (control), stored at -40C for one week (168h), 250C for one week (168h), -40C for two weeks (336h) and 250C for two weeks (336h). 30 apparently healthy subjects ranging between the ages of 23 to 75 years participated in the study. Materials and Methods: Standard analytical procedures were used to determine the levels of the lipoproteins in the sample. Results: The results of the means ± SD of the plasma samples in the different anticoagulants stored for both 1 week and 2weeks at -4°C and 25°C for TC, TG, HDL-C and LDL-C showed significant differences (p< 0.05) decrease and deterioration when compared with the controls. There was no significant difference (p>0.05) in the lipoprotein concentrations between lithium heparin and fluoride oxalate controls suggesting that lipoprotein determinations can be performed using fluoride oxalate as anticoagulant if the samples are to be analyzed immediately after collection. Conclusion: Anticoagulants, length and storage temperature, affect dramatically the measurement of total cholesterol, triglycerides, high density lipoprotein and low density lipoproteins.

Keywords: Lipoprotein, lithium heparin, fluoride oxalate, anticoagulants, storage, temperature.


[Full Text Article]

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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing Scholar Article Journal Index (SAJI) International Scientific Indexing ( ISI )