EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

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ISSN 2394-3211

Impact Factor: 7.065

ICV - 79.57

Abstract

ALUMINIUM SULPHATE IN PEG AS A GREEN RECYCLABLE HOMOGENEOUS CATALYTIC SYSTEM TO SYNTHESIS OF AMIDOALKYL NAPHTHOL

Bhata R. Chaudhari*

ABSTRACT

Aluminium sulphate as a catalyst in PEG as a reaction solvent is found to be an attractive, environmentally benign and highly efficient catalytic system for the one-pot multicomponent reaction of aromatic aldehyde, β-naphthol and amide to form the corresponding amidoalkyl naphthol. The procedure is simple, rapid and high yielding. Moreover, the catalyst exhibited a remarkable reactivity and is reusable in PEG-400 as a solvent. The Aluminium sulphate in PEG-400 can be reused upto four times without significant loss in yields and selectivity of the product. The remarkable features of this new one pot C-C and C-N bond forming reaction procedure are high conversations, operationally simple and eco-friendly and economically inexpensive method.

Keywords: Multicomponent reaction, amidoalkyl naphthol, ?-Naphthol, Aldehyde, Aluminium sulphate, PEG-400.

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