EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

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 ISSN 2394-3211

Impact Factor: 6.222

 ICV - 79.57

Abstract

ASSOCIATION OF HYPOXIA RESPONSIVENESS AND CELL TURNOVER IN ORAL SQUAMOUS CELL CARCINOMA

Dr. Jitender Prasad, *Dr. Anisha Sharma, Dr. Binita Goswami, Dr. Kiran Agarwal, Dr. Pravesh Mehra, Dr. Shilpa Kumar

ABSTRACT

Introduction: Oral cancer is one of the major health problems in India and Indian subcontinent countries. During the past few years, the association between cancer and raised uric acid has drawn a lot of attention. High cell turnover can lead to hyperuricemia and tumorigenesis implicating an underlying link between purine metabolism disorders and cancer. Objective: To evaluate serum levels of uric acid and hypoxia induced factor 1 alpha in oral cancer patients and compare them with those of healthy controls. Material and methods: 50 confirmed oral squamous cell cancer cases and controls had serum uric acid levels measured using timed end point method given by Fossati and Berti (1980) on spectrophotometer and HIF 1 alpha was measured by performing Sandwich ELISA. The data obtained was analyzed using the Statistical Package for the Social Sciences, version 20.0 (SPSS 20). Statistical significance was determined at p < 0.05. Results: Significant variation was observed in mean value of HIF 1 α in cases and control with normal (P value <0.05) as well as high (p value <0.001) uric acid levels. Conclusion: As hypoxia is a common feature of many cancers. HIF-1alpha is an essential component in changing the transcriptional response of tumours under hypoxia. Elevated uric acid may be a true risk factor for cancer incidence and mortality and mechanisms by which uric acid may contribute to cancer pathogenesis by increasing the expression of gene coding for HIF-1alpha.

Keywords: Oral squamous cell carcinoma, HIF-1alpha, Uric acid, Hypoxia, Tumour, Antioxidant.


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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing Scholar Article Journal Index (SAJI) International Scientific Indexing ( ISI )