SOLUBILITY AND DISSOLUTION RATE ENHANCEMENT OF RITONAVIR BY SOLID DISPERSION TECHNIQUE
Swathi and Y. Anand Kumar*
In this study Ritonavir a model class II drug is selected for increasing the solubility and dissolution by solid dispersion technique using skimmed milk powder. Solid dispersions were prepared by solvent evaporation and kneading method at three different ratios. The prepared solid dispersion were evaluated for solubility, drug content and in vitro drug release as well as interactions studies by FTIR, DSC and powder XRD. The FTIR, studies reveals there is no interaction between drug and polymer but the crystallinity was modifies to greater extent justified with XRD and DSC results. The solubility of ritonavir was increased linearly with increase in the concentration of skimmed milk powder. Overall the rank order of improvement in dissolution properties of pure ritonavir was method dependent viz., KNE > SE > PM and ratios in the order 1:3 > 1:1 > 3:1. One-way ANOVA was used to test the statistical significant difference between ritonavir and solid dispersions. Significant differences in the means of DP60 and DE60 were tested at 95% confidence. The DP60 and DE60 values of solid dispersions prepared by kneading and solvent evaporation method are significantly higher (P<0.05) when compared to DP60 and DE60 values of physical mixture and pure ritonavir.
Keywords: ritonavir, Skimmed milk powder, FTIR, XRD, DSC, In vitro dissolution.
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