EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

European Journal of Pharmaceutical and Medical Research (EJPMR) has indexed with various reputed international bodies like : Google Scholar , Indian Science Publications , InfoBase Index (In Process) , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , International Society for Research activity (ISRA) , Scientific Indexing Services (SIS) , Polish Scholarly Bibliography , Global Impact Factor (GIF) (Under Process) , Universal Impact Factor , International Scientific Indexing (ISI), UAE  , Index Copernicus , CAS (A Division of American Chemical Society) USA (Under Process) , Directory of Open Access Journal (DOAJ, Sweden, in process) , UDLedge Science Citation Index , CiteFactor , Directory Of Research Journal Indexing (DRJI) , Indian citation Index (ICI) , Journal Index (JI, Under Process) , Directory of abstract indexing for Journals (DAIJ) , Open Access Journals (Under Process) , Impact Factor Services For International Journals (IFSIJ) , Cosmos Impact Factor , Jour Informatics (Under Process) , Eurasian Scientific Journal Index (ESJI) , International Innovative Journal Impact Factor (IIJIF) , Science Library Index, Dubai, United Arab Emirates , Pubmed Database [NLM ID: 101669306] (Under Process) , IP Indexing (IP Value 2.40) , Web of Science Group (Under Process) , Directory of Research Journals Indexing , Scholar Article Journal Index (SAJI) , International Scientific Indexing ( ISI ) , 

 ISSN 2394-3211

Impact Factor: 6.222

 ICV - 79.57

Abstract

SOLUBILITY AND DISSOLUTION RATE ENHANCEMENT OF RITONAVIR BY SOLID DISPERSION TECHNIQUE

Swathi and Y. Anand Kumar*

ABSTRACT

In this study Ritonavir a model class II drug is selected for increasing the solubility and dissolution by solid dispersion technique using skimmed milk powder. Solid dispersions were prepared by solvent evaporation and kneading method at three different ratios. The prepared solid dispersion were evaluated for solubility, drug content and in vitro drug release as well as interactions studies by FTIR, DSC and powder XRD. The FTIR, studies reveals there is no interaction between drug and polymer but the crystallinity was modifies to greater extent justified with XRD and DSC results. The solubility of ritonavir was increased linearly with increase in the concentration of skimmed milk powder. Overall the rank order of improvement in dissolution properties of pure ritonavir was method dependent viz., KNE > SE > PM and ratios in the order 1:3 > 1:1 > 3:1. One-way ANOVA was used to test the statistical significant difference between ritonavir and solid dispersions. Significant differences in the means of DP60 and DE60 were tested at 95% confidence. The DP60 and DE60 values of solid dispersions prepared by kneading and solvent evaporation method are significantly higher (P<0.05) when compared to DP60 and DE60 values of physical mixture and pure ritonavir.

Keywords: ritonavir, Skimmed milk powder, FTIR, XRD, DSC, In vitro dissolution.


[Full Text Article]

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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing Scholar Article Journal Index (SAJI) International Scientific Indexing ( ISI )