EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

European Journal of Pharmaceutical and Medical Research (EJPMR) has indexed with various reputed international bodies like : Google Scholar , Indian Science Publications , InfoBase Index (In Process) , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , International Society for Research activity (ISRA) , Scientific Indexing Services (SIS) , Polish Scholarly Bibliography , Global Impact Factor (GIF) (Under Process) , Universal Impact Factor , International Scientific Indexing (ISI), UAE  , Index Copernicus , CAS (A Division of American Chemical Society) USA (Under Process) , Directory of Open Access Journal (DOAJ, Sweden, in process) , UDLedge Science Citation Index , CiteFactor , Directory Of Research Journal Indexing (DRJI) , Indian citation Index (ICI) , Journal Index (JI, Under Process) , Directory of abstract indexing for Journals (DAIJ) , Open Access Journals (Under Process) , Impact Factor Services For International Journals (IFSIJ) , Cosmos Impact Factor , Jour Informatics (Under Process) , Eurasian Scientific Journal Index (ESJI) , International Innovative Journal Impact Factor (IIJIF) , Science Library Index, Dubai, United Arab Emirates , Pubmed Database [NLM ID: 101669306] (Under Process) , IP Indexing (IP Value 2.40) , Web of Science Group (Under Process) , Directory of Research Journals Indexing , Scholar Article Journal Index (SAJI) , International Scientific Indexing ( ISI ) , 

 ISSN 2394-3211

Impact Factor: 6.222

 ICV - 79.57

Abstract

ANTI-INFLAMMATORY AND ANTI-DIABETIC ACTIVITY OF INDIAN PROPOLIS

Shubharani Ramnath* and Sivaram Venkataramegowda

ABSTRACT

Propolis is a natural product with broad spectrum of biological properties collected by Apis mellifera bee from buds and exudates of various plant species. The chemical composition of propolis is known to alter with geographical origin leading to variation in pharmacological activities. Propolis from various geographical origins have been evaluated for antioxidant, anti-microbial, anticancer, anti-inflammatory, hepatoprotective activities, however biological properties of Indian propolis have been scarcely studied. The anti-inflammatory and anti-diabetic potential of propolis collected from South India were determined. The in-vitro anti-inflammatory potential of propolis extracts were confirmed by inhibition of albumin denaturation and membrane stabilization assay. The anti- diabetic activity was studied by inhibition of alpha-amylase enzyme and non-enzymatic glycosylation of haemoglobin method. All the studied propolis ethanol extracts possess significant anti-inflammatory and anti-diabetic activity showed dose dependent inhibition of albumin denaturation, haemolysis, alpha-amylase and non-enzymatic glycosylation of haemoglobin. The percentage of inhibition was comparable with that of the standards. The results concluded that the Indian propolis can be a promising therapeutic agent for inflammation and diabetes.

Keywords: Apis mellifera, anti-inflammatory, anti–diabetic, albumin denaturation, Alpha-amylase, propolis.


[Full Text Article]

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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing Scholar Article Journal Index (SAJI) International Scientific Indexing ( ISI )