EVALUATION OF ANTI-UROLITHIACTIC ACTIVITY OF ETHANOLIC EXTRACT OF PHYLLANTHUS URINARIA AGAINST ETHYLENE GLYCOL INDUCED UROLITHIASIS IN WISTAR ALBINO RATS
Semeen Samreen* and K. Srilatha
Urinary stone disease is a common disorder estimated to occur in approximately 12% of the population, with a recurrence rate of 70â€“81% in males, and 47â€“60% in females. It is one of the third most common afflictions found in humans. The effect of oral administration of ethanolic extract of Phyllanthus urinaria has been studied in Wistar albino rats. Ethylene glycol feeding resulted in hyperoxaluria as well as increased renal excretion of serum calcium, creatinine, urea, uric acid, magnesium and phosphorus. Supplementation with ethanolic extract of Phyllanthus urinaria significantly reduced the elevated urinary oxalate, uric acid serum creatinine and serum calcium, creatinine, urea, uric acid, magnesium and phosphorus. The increased deposition of stone forming constituents in the kidneys of calculogenic rats was also significantly lowered by ethanolic extract of Phyllanthus urinaria. The results indicate that the ethanolic extract Phyllanthus urinaria is endowed with antiurolithic activity.
Keywords: Phyllanthus urinaria, Hyperoxaluria; Urolithiasis; Ethylene glycol.
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