( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

European Journal of Pharmaceutical and Medical Research (EJPMR) has indexed with various reputed international bodies like : Google Scholar , Indian Science Publications , InfoBase Index (In Process) , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , International Society for Research activity (ISRA) , Scientific Indexing Services (SIS) , Polish Scholarly Bibliography , Global Impact Factor (GIF) (Under Process) , Universal Impact Factor , International Scientific Indexing (ISI), UAE  , Index Copernicus , CAS (A Division of American Chemical Society) USA (Under Process) , Directory of Open Access Journal (DOAJ, Sweden, in process) , UDLedge Science Citation Index , CiteFactor , Directory Of Research Journal Indexing (DRJI) , Indian citation Index (ICI) , Journal Index (JI, Under Process) , Directory of abstract indexing for Journals (DAIJ) , Open Access Journals (Under Process) , Impact Factor Services For International Journals (IFSIJ) , Cosmos Impact Factor , Jour Informatics (Under Process) , Eurasian Scientific Journal Index (ESJI) , International Innovative Journal Impact Factor (IIJIF) , Science Library Index, Dubai, United Arab Emirates , Pubmed Database [NLM ID: 101669306] (Under Process) , IP Indexing (IP Value 2.40) , Web of Science Group (Under Process) , Directory of Research Journals Indexing , Scholar Article Journal Index (SAJI) , International Scientific Indexing ( ISI ) , 

 ISSN 2394-3211

Impact Factor: 6.222

 ICV - 79.57



Jude E. Enoh*, Benjamin D. Thumamo Pokam, Aniekan-Augusta O. Eyo, Ifeyinwa M. Okafor, Jules Clement Assob Nguedia, Boris T. Fominyam and Marcelin Ngowe Ngowe


Background: Antituberculosis drugs (ATD) have been known to efficiently combat Mycobacterium tuberculosis either due to the active principle itself or to its metabolites. The first line treatment regimen of tuberculosis (TB) patients which involves the intensive and continuation phase have been known to have some adverse effects. This study was carried out in the South West Region of Cameroon to determine the magnitude of drug induced hematological disorders (DIHD) in TB patients under treatment. Methods: Ninety six TB patients on ATD were enrolled and compared to 32 (control) individuals who were neither on ATD or any other treatment. In this hospital based cross sectional study, consenting participants records were reviewed for medical history and questionnaire issued. About 2ml of venous blood was collected and analyzed using automatic hematological analyzer. Results: DIHD was observed in 62 (64.58%) of the 96 patients as compared to 5/32 (15.63%) of the control group (p= 0.00000157). In the 62 patients, a combination of drug induced hematological disorder was recorded: 35 (56.45%) had agranulocytosis, 24 (38.71%) leucopenia, 23 (37.1%) anemia and 17 (27.42%) thrombocytopenia. Gender (p=0.173), age (p=0.461) and treatment duration (p=0.448) were not associated with DIHD. Conclusion: TB patients who receive standard ATD treatment do develop drug induced hematological disorders, with agranulocytosis the most commonly observed. Close monitoring of such patients is advocated, since as patients with agranulocytosis have been known to usually have a high risk of optimistic infections and will recommend that the dosage.

Keywords: Antituberculosis drugs; Hematological disorders; Agranulocytosis; South West Region, Cameroon.

[Full Text Article]



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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing Scholar Article Journal Index (SAJI) International Scientific Indexing ( ISI )