EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

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 ISSN 2394-3211

Impact Factor: 6.222

 ICV - 79.57

Abstract

COMPARATIVE STUDY OF INTRAVENOUS DEXMEDETOMIDINE AND INTRAVENOUS PROPOFOL INFUSION FOR MONITORED ANESTHESIA CARE IN PATIENTS UNDERGOING TYMPANOPLASTY UNDER LOCAL ANESTHESEIA.

*Dr. Sangeeta Bansal Agarwal, Dr. Shashank Shekhar, Dr. Sanjivani Karmarkar, Dr. Ankit Gupta, Dr. Rahul Gupta

ABSTRACT

Background and Aim: To get ideal sedative state in patients undergoing surgery in local anesthesia is challenging for Anesthesiologist. Our aim was to evaluate efficacy of intravenous Dexmedetomidine and intravenous Propofol infusion in patients undergoing Tympanoplasty in local anesthesia for monitored anesthesia care. Material and Methods: Ninety patients were randomly divided into two groups of 45 each. Group D patients were given I.V. Dexmedetomidine on initial loading dose of 1 g/kg for 10 minutes period followed by 0.2-0.7 g/kg/hr. Patients in group P were given I.V. Propofol 75 g/kg/min for 10 minutes followed by maintenance dose of 12.5-75 g/kg/min. Sedation level of patients were recorded regularly using Ramsay Sedation Scale. Besides that pulse, blood pressure, respiratory rate, saturation, rescue analgesia and any untoward effect were noted. Result: Dexmedetomidine and Propofol provide adequate sedation needed for MAC, but Propofol require rescue analgesia in three patients. The onset and recovery from sedation were earlier with Propofol. Mean heart rate was lower in Dexmedetomidine group and blood pressure was lower in the Propofol group. Both the drug doesn’t affect respiration. Patients of Dexmedetomidine group develop dryness of mouth. Conclusions: Both Dexmedetomidine and Propofol were effective in providing monitored anaesthesia care, but Dexmedetomidine was found to be better drug as it provides hemodynamic stability, additional rescue analgesia and better sedation.

Keywords: Dexmedetomidine, Local anaesthesia, Monitored Anaesthesia Care, Propofol and Tympanoplasty.


[Full Text Article]

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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing Scholar Article Journal Index (SAJI) International Scientific Indexing ( ISI )