EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

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 ISSN 2394-3211

Impact Factor: 6.222

 ICV - 79.57

Abstract

HYPERTRIGLYCERIDEMIA IN SUDANESE CHILDREN WITH SICKLE CELL DISEASE

Eltayeb Tayrab*, Mouna Samaan and Khalid Awad E. Ahmed

ABSTRACT

Sickle cell disease (SCD) is the most common serious genetic disorder in Sudan; which characterized by red cells rigidity and abnormal viscoelasticity of cell membrane, that affect the plasma lipid profile. The aim of this study was to evaluate lipid profile in children with HbSS in Gaafer Ibn Oof children’s Hospital in Khartoum, Sudan. This case control study was done in 100 children; 50 of them were with sickle cell disease (HbSS) and another 50 were healthy children (HbAA), who were age and sex matched; served as control. The mean age of the children with SCD was (7.6±4.27years), versus (7.15±4.19 years) in control subjects. After overnight fasting; serum lipid profile was done using automated chemical analyzer. The mean triglycerides in SCD group was (151.6±5.6 mg/dl), versus (124.3±4.0 mg/dl); with P value (0.001), total cholesterol was (102.9±5.0mg/dl), versus (140.8±4.6mg/dl); with P value (0.000), HDL was (25.2±1.3mg/dl), versus (35.1±1.6 mg/dl); P value (0.000), LDL was (46.8±3.9 mg/dl), versus (54.6±1.5 mg/dl), VLDL was (30.3±1.3mg/dl) versus (24.9±0.8mg/dl) and atherogenic index was (1.21±0.55) versus (1.15±0.42); respectively. In SCD group; serum triglycerides significantly increased; while total cholesterol and high density lipoproteins significantly decreased. Conclusion: hypertriglyceridemia is predominant in Sudanese children with sickle cell disease; while total cholesterol and high density lipoproteins significantly reduce; these lipid abnormalities could represent a cardiovascular risk factor for the children with sickle cell disease.

Keywords: triglycerides, cholesterol, lipoproteins, serum, sickle cell disease, Sudan.


[Full Text Article]

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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing Scholar Article Journal Index (SAJI) International Scientific Indexing ( ISI )