A REVIEW ON CHALCONES
Vudumula Kotireddy* and K. Venkata Ramana
The chalcones are important intermediates in the synthesis of pyrazoles, isoxazoles, pyrimidines and other
heterocyclic systems. The compounds with chalcone as backbone have been reported to possess varied biological
and pharmacological activities, including antimicrobial, anti-inflammatory, analgesic, cytotoxic, antitumor,
antimalarial, antitubercular, antiviral, anti-HIV, antiulcerative, antileishmanial, antioxidant, antiprotozoal,
antihistaminic, antifedent, immunomodulatory, anticonvulsant, antihyperglycemic, antihyperlipidemic and
antiplatelet activities. the review describes a brief account of various modifications reported on chalcones, which
resulted in a variety of biological and pharmacological activities.
Keywords: Chalcones, Pyrazoles, Isoxazoles, Pyrimidines.
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