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An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

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European Journal of Pharmaceutical and Medical Research (EJPMR) has indexed with various reputed international bodies like : Google Scholar , Indian Science Publications , InfoBase Index (In Process) , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , International Society for Research activity (ISRA) , Scientific Indexing Services (SIS) , Polish Scholarly Bibliography , Global Impact Factor (GIF) (Under Process) , Universal Impact Factor , International Scientific Indexing (ISI), UAE  , Index Copernicus , CAS (A Division of American Chemical Society) USA (Under Process) , Directory of Open Access Journal (DOAJ, Sweden, in process) , UDLedge Science Citation Index , CiteFactor , Directory Of Research Journal Indexing (DRJI) , Indian citation Index (ICI) , Journal Index (JI, Under Process) , Directory of abstract indexing for Journals (DAIJ) , Open Access Journals (Under Process) , Impact Factor Services For International Journals (IFSIJ) , Cosmos Impact Factor , Jour Informatics (Under Process) , Eurasian Scientific Journal Index (ESJI) , International Innovative Journal Impact Factor (IIJIF) , Science Library Index, Dubai, United Arab Emirates , Pubmed Database [NLM ID: 101669306] (Under Process) , IP Indexing (IP Value 2.40) , Web of Science Group (Under Process) , Directory of Research Journals Indexing , Scholar Article Journal Index (SAJI) , International Scientific Indexing ( ISI ) , Scope Database , Academia , 

 ISSN 2394-3211

Impact Factor: 7.065

 ICV - 79.57



Ejikeugwu Chika*, Iroha Ifeanyichukwu, Orji Jerry, Ugwu Malachy, Okonkwo Eucharia, Ikegbunam Moses, Ugbo Emmanuel, Moses Ikechukwu,
Nwakaeze Emmanuel


The emergence of newer beta-lactamases such as extended spectrum beta-lactamases (ESBLs) is an important mechanism by which pathogenic bacteria develop resistance to some commonly available drugs; and this trend is of global concern due to the multidrug resistant nature of such microbes. ESBLs are plasmid-mediated beta- lactamases capable of hydrolyzing oxyimino 3rd-generation cephalosporins and monobactams but are yet inhibited by clavulanic acid (a beta-lactamase inhibitor). Fifty (50) clinical isolates of Pseudomonas aeruginosa was tested phenotypically by the double disk synergy test (DDST) method for ESBL production. Only 11 P. aeruginosa isolates (22 %) produced ESBLs phenotypically. The ESBL-producing P. aeruginosa isolates in this study were completely resistant to sulphamethoxazole-trimethoprim (100 %). Higher levels of resistance amongst the ESBL-positive P. aeruginosa were also recorded for ceftazidime (90.1 %), cefotaxime (90.1 %), gentamicin (72.7 %), ciprofloxacin (54.5) and ofloxacin (81.8 %). Nonetheless, the ESBL-positive P. aeruginosa isolates were highly susceptible to imipenem and meropenem which are both carbapenems; and are the drug of choice for treating infections caused by ESBL-positive bacteria. The high level of resistance of ESBL-positive bacteria to some commonly available antibiotics (as obtainable in this study) gibes impetus to the antibiotic degrading capability of microbes expressing this enzyme. It is critical for hospitals (especially in this part of the globe) to always be on the lookout for multidrug resistant pathogens inclusive of those expressing ESBLs in order to contain any outbreak due to them.

Keywords: Pseudomonas aeruginosa, ESBLs, Nosocomial, Antibiogram.

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  • New Issue Published

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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing Scholar Article Journal Index (SAJI) International Scientific Indexing ( ISI ) Scope Database Academia