EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

European Journal of Pharmaceutical and Medical Research (EJPMR) has indexed with various reputed international bodies like : Google Scholar , Indian Science Publications , InfoBase Index (In Process) , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , International Society for Research activity (ISRA) , Scientific Indexing Services (SIS) , Polish Scholarly Bibliography , Global Impact Factor (GIF) (Under Process) , Universal Impact Factor , International Scientific Indexing (ISI), UAE , Index Copernicus , CAS (A Division of American Chemical Society) USA (Under Process) , Directory of Open Access Journal (DOAJ, Sweden, in process) , UDLedge Science Citation Index , CiteFactor , Directory Of Research Journal Indexing (DRJI) , Indian citation Index (ICI) , Journal Index (JI, Under Process) , Directory of abstract indexing for Journals (DAIJ) , Open Access Journals (Under Process) , Impact Factor Services For International Journals (IFSIJ) , Cosmos Impact Factor , Jour Informatics (Under Process) , Eurasian Scientific Journal Index (ESJI) , International Innovative Journal Impact Factor (IIJIF) , Science Library Index, Dubai, United Arab Emirates , Pubmed Database [NLM ID: 101669306] (Under Process) , IP Indexing (IP Value 2.40) , Web of Science Group (Under Process) , Directory of Research Journals Indexing , Scholar Article Journal Index (SAJI) , International Scientific Indexing ( ISI ) , Scope Database , Academia ,

ISSN 2394-3211

Impact Factor: 7.065

ICV - 79.57

Abstract

TOXICITIES OF LEUNASE (L â€“ ASPARAGINASE) ADMINISTRATION IN NORMAL HEALTHY RABBITS

Khwaja Ali Hasan, *Aziza Khanam and Sidra Rizwan

ABSTRACT

In the present study the effect of leunase (L-asparaginase) was investigated on healthy rabbits. The healthy rabbits were grouped into control and L-asparaginase treated animal. The L-asparaginase group rabbits had shown an increase in the level of serum glucose, amylase, urea and creatinine after 3 doses of 100 I.U. L-asparaginase on the 7th day of experiment, where as the level of serum protein in markedly decreased on 7th day of L-asparginase treatment. These observations suggest intervention strategies during the L-asparaginase treatment of acute lymphoblastic leukemic patients and the patients clinical monitoring for early diagnosis of these complication, is recommended.

Keywords: L-asparaginase, Amylase, Glucose, Urea, Creatinine.

[Full Text Article] [Download Certificate]