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An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

European Journal of Pharmaceutical and Medical Research (EJPMR) has indexed with various reputed international bodies like : Google Scholar , Indian Science Publications , InfoBase Index (In Process) , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , International Society for Research activity (ISRA) , Scientific Indexing Services (SIS) , Polish Scholarly Bibliography , Global Impact Factor (GIF) (Under Process) , Universal Impact Factor , International Scientific Indexing (ISI), UAE  , Index Copernicus , CAS (A Division of American Chemical Society) USA (Under Process) , Directory of Open Access Journal (DOAJ, Sweden, in process) , UDLedge Science Citation Index , CiteFactor , Directory Of Research Journal Indexing (DRJI) , Indian citation Index (ICI) , Journal Index (JI, Under Process) , Directory of abstract indexing for Journals (DAIJ) , Open Access Journals (Under Process) , Impact Factor Services For International Journals (IFSIJ) , Cosmos Impact Factor , Jour Informatics (Under Process) , Eurasian Scientific Journal Index (ESJI) , International Innovative Journal Impact Factor (IIJIF) , Science Library Index, Dubai, United Arab Emirates , Pubmed Database [NLM ID: 101669306] (Under Process) , IP Indexing (IP Value 2.40) , Web of Science Group (Under Process) , Directory of Research Journals Indexing , Scholar Article Journal Index (SAJI) , International Scientific Indexing ( ISI ) , Scope Database , Academia , 

 ISSN 2394-3211

Impact Factor: 7.065

 ICV - 79.57



Dr. Harini G.L. and Dr. Raveendra K.R. MD


Introduction: Metabolic syndrome or syndrome X is a cluster of risk factors (diabetes, prediabetes, abdominal obesity, hypertension and dyslipidemias) for the development of cardiovascular disease. The prevalence of Metabolic Syndrome worldwide is 20-25%. Although GGT is a less specific marker of liver function, higher GGT levels have also been linked with obesity, physical inactivity, hypertension, dyslipidemias, and hyperinsulinemia, implying that elevated GGT belongs in the cluster of the metabolic syndrome. And it has been shown that risk for the individual metabolic syndrome components increased as the baseline GGT levels increased. It has been clearly demonstrated that serum GGT levels elevated even within normal range are associated with some atherosclerotic risk factors. Although the exact mechanism responsible for this association is unknown, several possible mechanisms have been proposed for the role of serum GGT in increasing cardiovascular risk. The most widely accepted mechanism is oxidative stress, followed by hepatic insulin resistance and subclinical inflammation.Raised liver enzymes, as relatively sensitive and easily obtained markers of non alcoholic fatty liver disease, reflect chronic ectopic fat deposition in the liver that may be useful in diagnosis of metabolic syndrome. High liver function tests, especially GGT levels, are associated with prevalent metabolic syndrome and in this aspect they may have a predictive value in diagnosis of metabolic syndrome. Objectives 1. To study the association of gamma glutamyl Transferase with metabolic syndrome. 2. To assess the sensitivity and specificity of GGT in the diagnosis of metabolic syndrome. Methods: In a cross sectional study of 100 subjects, 50 were taken as cases and 50 as controls, after fulfilling necessary inclusion and exclusion criteria and relevant investigations were done including estimation of gamma glutamyl transferase in all.Results A total of 100 subjects were chosen in the study with 50 as study population and the other 50 as controls, investigations were done as mentioned and their gamma glutamyl transferase levels were assessed.The estimated GGT values were high in 35(70%) of cases showing moderate elevation and7(14%) cases showing severe elevation. The mean GGT among the cases is 48.18±14.68 and that among controls is 30.96±10.06 with a very significant p value of <0.001.The sensitivity and specificity of gamma glutamyl transferase in diagnosis of metabolic syndrome was found to be 92% and 88% respectively. Conclusion: Elevated levels of GGT were found to be associated with metabolic syndrome. GGT was found to be more specific than the other liver enzymes which are also raised in metabolic syndrome. Sensitivity of 92% and specificity of 88% makes gamma glutamyl transferase a good marker for diagnosis of metabolic syndrome.

Keywords: metabolic syndrome, gamma glutamyl transferase.

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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing Scholar Article Journal Index (SAJI) International Scientific Indexing ( ISI ) Scope Database Academia