EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

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 ISSN 2394-3211

Impact Factor: 6.222

 ICV - 79.57

Abstract

IN VIVO ASSESSMENT OF IMMUNOMODULATORY ACTIVITY OF WITHANIA COAGULANS DUNAL FRUITS

Archana K. Shendkar*, Sugandha G. Chaudhari, Usama Khan and Dr. Yogesh K. Shendkar

ABSTRACT

The aim of the study was to investigate the immunomodulatory activity using methanolic and hydro-alcoholic extracts of Withania Coagulans dunal fruits i.e. Withania Coagulans Methanolic Extract (WCME) and Withania Coagulans Hydroalcoholic Extract (WCHAE). Phytochemical analysis has indicated presence of alkaloids, flavonoids, glycosides, steroids, saponins, fixed oil, carbohydrates. Both the extracts have showed immunomodulatory activity by Serum hemagglutinin titer assay. The agglutination reaction between test serum antibodies and antigen (mesh formation) present in Sheep Red Blood Cell’s effectively inhibited by 75%, 77.77% in standard (Methotrexate), 40%, 44.44% in WCME-100 mg/kg, 55.55%, 60% in WCME-200 mg/kg, 50%, 66.66% in WCHAE-100 mg/kg, 70%, 75% in WCHAE-200 mg/kg groups in comparison with agglutination of control group wells in micro-titer plates. Both the extracts showed the good immunomodulatory activity but WCHAE showed the most significant immunomodulatory activity than WCME. The findings of the present study suggested that Withania Coagulans dunal fruits could be a potential natural source of immunomodulatory activity which is very important against treatment of immune system disease.

Keywords: immunomodulatory, Withania Coagulans, Setumhemagglutinin titer, agglutination.


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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing