FORMULATION DEVELOPMENT AND EVALUATION OF FAST DISINTEGRANTS SUBLINGUAL TABLETS CONTAINING METHYLCOBALAMIN AND CHOLECALCIFEROL FOR DIABETIC NEUROPATHY
K. Mohan Kumar*, R. Rama Sumaliya and Stephen. P
The demand of fast disintegrating sublingual tablets has been growing during the last decade especially for geriatric and paediatrics patients because of swallowing difficulties and its characteristics for the potential emergency treatment. The aim of this study was to prepare fast disintegrating tablets of Methylcobalamin and Cholecalciferol by using different disintegrant in different concentration and to evaluate the effect of increase Methylcobalamin and Cholecalciferol load on the characteristic of fast disintegrating sublingual tablets for the treatment of diabetic neuropathy. The sublingual tablets were prepared by direct compression method using various concentration of croscarmellose sodium, sodium starch glycolate and crosprovidone, drug compatibility was confirmed by using FTIR and showed no drug–exicipient interaction, Six formulation (R1-R6) of sublingual tablets were prepared by using the various concentration of fast disintegrants were evaluated for thickness, hardness, Weight variation, friability, wetting time, water absorption ratio, disintegration time and drug content. The optimized formulation F6 with 5% croscarmellose sodium was found to be suitable which provided short wetting time 25.7sec, Water absorption ratio 21.28sec and disintegration time of 21 sec which is within pharmaceutical limits.
Keywords: Methylcobalamin, Cholecalciferol, Fast disintegration, Sublingual tablets, croscarmellose sodium, In-vitro disintegration.
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