EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

European Journal of Pharmaceutical and Medical Research (EJPMR) has indexed with various reputed international bodies like : Google Scholar , Indian Science Publications , InfoBase Index (In Process) , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , International Society for Research activity (ISRA) , Scientific Indexing Services (SIS) , Polish Scholarly Bibliography , Global Impact Factor (GIF) (Under Process) , Universal Impact Factor , International Scientific Indexing (ISI), UAE  , Index Copernicus , CAS (A Division of American Chemical Society) USA (Under Process) , Directory of Open Access Journal (DOAJ, Sweden, in process) , UDLedge Science Citation Index , CiteFactor , Directory Of Research Journal Indexing (DRJI) , Indian citation Index (ICI) , Journal Index (JI, Under Process) , Directory of abstract indexing for Journals (DAIJ) , Open Access Journals (Under Process) , Impact Factor Services For International Journals (IFSIJ) , Cosmos Impact Factor , Jour Informatics (Under Process) , Eurasian Scientific Journal Index (ESJI) , International Innovative Journal Impact Factor (IIJIF) , Science Library Index, Dubai, United Arab Emirates , Pubmed Database [NLM ID: 101669306] (Under Process) , IP Indexing (IP Value 2.40) , Web of Science Group (Under Process) , Directory of Research Journals Indexing , 

 ISSN 2394-3211

Impact Factor: 6.222

 ICV - 79.57

Abstract

FORMULATION DEVELOPMENT AND EVALUATION OF FAST DISINTEGRANTS SUBLINGUAL TABLETS CONTAINING METHYLCOBALAMIN AND CHOLECALCIFEROL FOR DIABETIC NEUROPATHY

K. Mohan Kumar*, R. Rama Sumaliya and Stephen. P

ABSTRACT

The demand of fast disintegrating sublingual tablets has been growing during the last decade especially for geriatric and paediatrics patients because of swallowing difficulties and its characteristics for the potential emergency treatment. The aim of this study was to prepare fast disintegrating tablets of Methylcobalamin and Cholecalciferol by using different disintegrant in different concentration and to evaluate the effect of increase Methylcobalamin and Cholecalciferol load on the characteristic of fast disintegrating sublingual tablets for the treatment of diabetic neuropathy. The sublingual tablets were prepared by direct compression method using various concentration of croscarmellose sodium, sodium starch glycolate and crosprovidone, drug compatibility was confirmed by using FTIR and showed no drug–exicipient interaction, Six formulation (R1-R6) of sublingual tablets were prepared by using the various concentration of fast disintegrants were evaluated for thickness, hardness, Weight variation, friability, wetting time, water absorption ratio, disintegration time and drug content. The optimized formulation F6 with 5% croscarmellose sodium was found to be suitable which provided short wetting time 25.7sec, Water absorption ratio 21.28sec and disintegration time of 21 sec which is within pharmaceutical limits.

Keywords: Methylcobalamin, Cholecalciferol, Fast disintegration, Sublingual tablets, croscarmellose sodium, In-vitro disintegration.


[Full Text Article]

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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing