DURATIONAL ENHANCED ANTIULCEROGENIC POTENTIALS OF ALOE VERA WITH OMEPRAZOLE IN GASTRIC ULCER
Jimmy E. O.* and Udim N. A.
A comparative study of curative potentials of Aloe Vera juice with proton pump inhibitor; omeprazole was carried on 30 adult albino wister rats for the period of 28 days. Rats administered with 122.47mg/kg of Aloe Vera juice had decrease (P<0.05) in ulceration i.e high rate of ulcer healing but there was a significant increase (P < 0.01) in gastric acid secretion compared to omeprazole and control
groups. However, there was a significant decrease (P<0.01) in gastric output but increase in ulceration, (P<0.05) in omeprazole treated group than in Aloe Vera and the control groups. Clinically gastric ulceration predisposes to morbidity and mortality rates. It is concluded that Aloe Vera juice could be used as combined therapy with omeprazole in the treatment of gastric ulcer.
Keywords: Aloe Vera, omeprazole, gastric acidity, ulcer scores.
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