EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

European Journal of Pharmaceutical and Medical Research (EJPMR) has indexed with various reputed international bodies like : Google Scholar , Indian Science Publications , InfoBase Index (In Process) , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , International Society for Research activity (ISRA) , Scientific Indexing Services (SIS) , Polish Scholarly Bibliography , Global Impact Factor (GIF) (Under Process) , Universal Impact Factor , International Scientific Indexing (ISI), UAE  , Index Copernicus , CAS (A Division of American Chemical Society) USA (Under Process) , Directory of Open Access Journal (DOAJ, Sweden, in process) , UDLedge Science Citation Index , CiteFactor , Directory Of Research Journal Indexing (DRJI) , Indian citation Index (ICI) , Journal Index (JI, Under Process) , Directory of abstract indexing for Journals (DAIJ) , Open Access Journals (Under Process) , Impact Factor Services For International Journals (IFSIJ) , Cosmos Impact Factor , Jour Informatics (Under Process) , Eurasian Scientific Journal Index (ESJI) , International Innovative Journal Impact Factor (IIJIF) , Science Library Index, Dubai, United Arab Emirates , Pubmed Database [NLM ID: 101669306] (Under Process) , IP Indexing (IP Value 2.40) , Web of Science Group (Under Process) , Directory of Research Journals Indexing , 

 ISSN 2394-3211

Impact Factor: 6.222

 ICV - 79.57

Abstract

PHYTOCHEMICAL, ANTIOXIDANT AND ANTIBACTERIAL POTENTIAL OF EXTRACTS OF CICHORIUM INTYBUS (CHICORY)

Harjot Pal Kaur*, Inderjeet Singh and Nitee Singh

ABSTRACT

The Kasni, Cichorium intybus (C. intybus) is well known traditional herb included in many systems of medicine like Ayurveda, Unani and Siddha. Keeping in view its medicinal value phytochemical, antioxidant and antibacterial analysis of extracts of leaves and roots of C. intybus was carried out. Phytochemical analysis revealed the presence of diterpenes, alkaloids, flavonoids, proteins, amino acids, saponins, phenols, phytosterols and tannins in the extracts but glycosides, cardiac glycosides and carbohydrates were absent. Antioxidants were determined by total phenolic content (TPC) and DPPH free radical scavenging activity. Methanol extracts of leaves and roots exhibited maximum phenolic content and DPPH free radical scavenging activity followed by chloroform extracts and aqueous extracts of leaves and roots. As the concentration of extracts increases from 10μg/ml to 100μg/ml the scavenging effect also increases for all the extracts. The antibacterial activity against S. aureus, B. subtilis, E. coli and P. aeruginosa shows that methanol and chloroform extracts of leaves and roots had significant antibacterial activity with maximum zone of inhibition against E. coli. But aqueous extracts of leaves and roots exhibited highest antibacterial activity against P. aeruginosa. It is concluded from the results that C. intybus has potential source of natural antioxidants and can be used for the treatment of diseases caused by the test organisms. Due to good phytochemical, antioxidant and antibacterial composition, C. intybus would be valuable candidate in pharmaceutical formulations and play an important role in improving the human, livestock and poultry health by participating in the antioxidant defence system against endogenous free radicals and disease causing bacteria.

Keywords: Alkaloids, Antibacterial, Free radicals, Hexane, Phenolic content.


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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing