ANTIMICROBIAL IN VITRO PHARMACOLOGICAL STUDIES OF SOME PYRAZOLYL QUINAZOLIN-4(3H) ONE DERIVATIVES
Gaman G. Barat*
Some pyrazolylquinazolin-4(3H) one derivatives were synthesized by the base catalysed cyclisation of acrylamide with 3:5-dinitrophenyl hydrazine hydrate. The overall reaction was carried out by multistep process. The structural confirmation of the synthesized compounds was carried out on the basis of elemental analysis, IR and NMR spectra results. The title compounds were screened for antibacterial and antifungal pharmacological studies in vitro by cup plate method. The potency of synthesized compounds focus on the strength compared with standard drug.
Keywords: Antibacterial, Antifungal, Acrylamide, Quinazolin-4(3H) one.
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