EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

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 ISSN 2394-3211

Impact Factor: 6.222

 ICV - 79.57

Abstract

ANTI-BIOFILM POTENTIALITY OF ALTERNANTHERA PHILOXEROIDES: A STUDY WITH METHANOLIC PLANT EXTRACT.

Abhijit Bhattacharjee, Anamika Das, Manash C. Das, Antu Das and Surajit Bhattacharjee*

ABSTRACT

Alternanthera philoxeroides is a well-known ethnomedicinal plant of Tripura. Ethnic communities of the state use several parts including aerial parts and leaves of this plant for the treatment of several ailments like stomach infection, diarrhoea, appetiser etc. With this background we have proposed to perform chemical characterisation, investigation of antimicrobial and antibiofilm potentiality of methanolic extract of aerial parts of Alternanthera philoxeroides (APME) against biofilm causing model microorganism Pseudomonas aeruginosa. Biofilms are clustered form of microorganisms attached to a substratum. Biofilm causing microorganisms (e.g. Pseudomonas aeruginosa) have been found to cause chronic inflammatory, infectious diseases and can become resistant to antibiotics. In the present study, APME has shown the presence of UV active phytochemicals as evident from UV-Vis spectroscopy and biochemical colour tests. APME has executed maximum 65.23% antimicrobial activity against Pseudomonas aeruginosa at 100 μg/ml dose. At sub-inhibitory dose (10 μg/ml), APME has exerted maximum 32.57% antibiofilm activity as analysed by safranin staining, protein extraction and EPS quantification assay. Effect of APME on attenuation of bacterial biofilm was validated by observation under fluorescent microscope. The extract at 10 μg/ml concentration also executes maximum attenuation in bacterial swarming motility. All these findings suggest that APME is a potential phyto-therapeutic extract which may be employed to formulate preventive strategies against biofilm associated infections caused by P. aeruginosa.

Keywords: Alternanthera philoxeroides, Pseudomonas areuginosa, Antimicrobial, Antibiofilm, Motility.


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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing