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An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

European Journal of Pharmaceutical and Medical Research (EJPMR) has indexed with various reputed international bodies like : Google Scholar , Indian Science Publications , InfoBase Index (In Process) , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , International Society for Research activity (ISRA) , Scientific Indexing Services (SIS) , Polish Scholarly Bibliography , Global Impact Factor (GIF) (Under Process) , Universal Impact Factor , International Scientific Indexing (ISI), UAE  , Index Copernicus , CAS (A Division of American Chemical Society) USA (Under Process) , Directory of Open Access Journal (DOAJ, Sweden, in process) , UDLedge Science Citation Index , CiteFactor , Directory Of Research Journal Indexing (DRJI) , Indian citation Index (ICI) , Journal Index (JI, Under Process) , Directory of abstract indexing for Journals (DAIJ) , Open Access Journals (Under Process) , Impact Factor Services For International Journals (IFSIJ) , Cosmos Impact Factor , Jour Informatics (Under Process) , Eurasian Scientific Journal Index (ESJI) , International Innovative Journal Impact Factor (IIJIF) , Science Library Index, Dubai, United Arab Emirates , Pubmed Database [NLM ID: 101669306] (Under Process) , IP Indexing (IP Value 2.40) , Web of Science Group (Under Process) , Directory of Research Journals Indexing , Scholar Article Journal Index (SAJI) , International Scientific Indexing ( ISI ) , Scope Database , 

 ISSN 2394-3211

Impact Factor: 6.222

 ICV - 79.57



Hashim DafaAllah Mohammed Ahmed Badie*, Ahmed Abdelbadie, Munsoor Mohammed Munsoor and Khalid Eltahir Khalid


Background/Objectives: Recently, oral cancer mortality and morbidity is very high in Sudan, particularly among men due to environmental factors and habits of life style. The study aimed to investigate the frequency of mitochondrial DNA (D- loop) mutations (mtDNA4977) in oral lesions. Materials and Methods: This is a retrospective study on oral lesions biopsies in Khartoum state - Sudan. The data were collected from examination of biopsies and patients records. All oral biopsies were examined and classified into histopathological pattern by using hematoxylin & eosin standard method. The detection of mtDNA4977 bp deletion was performed using a PCR-based technique. Data was analyzed by using the statistical package for social sciences (SPSS) for Windows computing program version 20. Results: One hundred and fifteen oral biopsies were taken from patients during surgical operation (61 male; 54 female), their mean age was 47±18. Of the study samples, 81 (70.4%) samples were malignant, 18 (15.7%) were benign and 12 (10.4%) were inflamed. Squamous cell carcinoma was the most frequent 55 (67.9%) of malignant cases, followed by adenocarcinoma 15 (18.5%), mucoepidermoid carcinoma 5 (6.2%), ameblastoma 4 (4.9%), and lymphoma 2 (2.5%). Four of the malignant cases (1 male and 3 female) were having the 4,977 -bp deletion. Conclusions: It could be concluded that there was no obvious correlation between 4.977 bp deletion and prognostic indicators among Sudanese with oral lesions, which limits it`s utility as prognostic biomarker in oral disease. The study suggested further large scale studies in order to increase the rate of mutation detection.

Keywords: mitochondrial DNA, 4.977 bp deletion, Oral lesions, Sudanese patients.

[Full Text Article]



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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing Scholar Article Journal Index (SAJI) International Scientific Indexing ( ISI ) Scope Database