EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

European Journal of Pharmaceutical and Medical Research (EJPMR) has indexed with various reputed international bodies like : Google Scholar , Indian Science Publications , InfoBase Index (In Process) , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , International Society for Research activity (ISRA) , Scientific Indexing Services (SIS) , Polish Scholarly Bibliography , Global Impact Factor (GIF) (Under Process) , Universal Impact Factor , International Scientific Indexing (ISI), UAE  , Index Copernicus , CAS (A Division of American Chemical Society) USA (Under Process) , Directory of Open Access Journal (DOAJ, Sweden, in process) , UDLedge Science Citation Index , CiteFactor , Directory Of Research Journal Indexing (DRJI) , Indian citation Index (ICI) , Journal Index (JI, Under Process) , Directory of abstract indexing for Journals (DAIJ) , Open Access Journals (Under Process) , Impact Factor Services For International Journals (IFSIJ) , Cosmos Impact Factor , Jour Informatics (Under Process) , Eurasian Scientific Journal Index (ESJI) , International Innovative Journal Impact Factor (IIJIF) , Science Library Index, Dubai, United Arab Emirates , Pubmed Database [NLM ID: 101669306] (Under Process) , IP Indexing (IP Value 2.40) , Web of Science Group (Under Process) , Directory of Research Journals Indexing , 

 ISSN 2394-3211

Impact Factor: 6.222

 ICV - 79.57

Abstract

ROLE OF CANCER STEM CELLS IN CERVICAL CANCER

Pooja Singh, Anand Narain Srivastava, Alka Singh, Alok Singh*, Rajveer Singh Chauhan, Siddhartha Chandel

ABSTRACT

In spite of screening and vaccination programmes, cervical cancer has become a foremost reason of cancer related deaths in women. Chemotherapy and surgery is involve in prolong survival in the patients but not give the permanent cure to patients of cervical cancer. Radical surgery is the only option for the cervical cancer at their advance stage, which also affects the childbearing capacity of the patients. Sometime it also results in the recurrence of the disease. Therefore, there is an urgent requirement to develop novel therapeutics. Hypothesis of CSCs have reported about a tumor possesses hierarchical cellular structure containing small subset of cells named as cancer stem cells inducing tumorigenesis. Many studies have reported about the CSCs tumor – initiating capacity, These CSCs play an important roles in metastasis of tumor, relapse and chemo radio-resistance. They are considered for the better outcome because they involve in the initiation of tumor propagation. The most common gynaecological malignancy is cervical carcinoma and in females it shows a high cancer mortality rate. Therefore, cervical cancer stem cells has emerged as an keen player in investigation of cervical cancer. Herein, this review, we have summarized CSCs and CCSCs as an emerging key role player in early diagnosis of cervical cancer and as a therapeutic target in this cancer.

Keywords: Cervical Cancer, Cancer Stem Cell, Cervical Cancer Stem Cell, Human Papilloma Virus.


[Full Text Article]

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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing