EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

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 ISSN 2394-3211

Impact Factor: 6.222

 ICV - 79.57

Abstract

STUDY OF INTERLEUKIN-6 (IL- 6) LEVELS IN PERINATAL ASPHYXIA AND ITS CORRELATION WITH DIFFERENT STAGES OF HYPOXIC ISCHEMIC ENCEPHALOPATHY

Dr. Sudhir Mehta*

ABSTRACT

Introduction: Perinatal asphyxia is a major cause of neurologic morbidity in infants. Hypoxic ischemic encephalopathy (HIE)after perinatal asphyxia is a condition in which serum concentration of brain specific biochemical markers may be elevated. Neuroprotective interventions in asphyxiated newborns require early indicators of brain damage to initiate therapy. There are very few studies about its usefulness in asphyxiated newborns. Aims and Objectives: To determine the serum levels of interleukin-6 (IL-6) in newborns with perinatal asphyxia and its relationwith different stages of HIE. Methods: We have measured the serum values of IL-6 by enzyme linked immunosorbant assay method in 80 asphyxiatednewborns and 80 healthy newborns (control group). Blood samples were taken on day 1 and day 3 of life in all newborns. Results: The mean serum values of IL-6 were found to be decreased on day 3 in asphyxiated neonates and a negativecorrelation was seen between day 1 and 3 for IL-6. The mean values of IL-6 were decreased in different stages of HIE on day 3 as compared to day 1 and a negative correlation was observed between day 1 and day 3 for IL-6 in no HIE, HIE I, HIE II and HIE III stages. Conclusion: We conclude that serum IL-6 concentrations increased considerably after birth asphyxia, and the increase isassociated with the severity of HIE with a poorer outcome.

Keywords: perinatal asphyxia, Hypoxic-ischemic encephalopathy, Interleukin-6.


[Full Text Article]

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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing Scholar Article Journal Index (SAJI) International Scientific Indexing ( ISI )