EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

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 ISSN 2394-3211

Impact Factor: 6.222

 ICV - 79.57

Abstract

CHEMICAL COMPOSITION AND ANTIMICROBIAL ACTIVITY OF THE EXTRACT FROM ANTHEMIS COELOPODA BOISS. VAR. COELOPODA STEMS AND ROOTS.

Reihaneh Abolhassani Chimeh Pharm D., Abdolhossein Rustaiyan Prof* and Setareh Haghighat PhD

ABSTRACT

The global increasing of bacterial drug resistance as well as the serious side effects of pharmaceutical chemicals, have encouraged researchers to focus on alternative drugs. Plants are able to make compounds with important biological effects such as anti-bacterial activities. Therefore research about anti-bacterial activities of plants as a natural source has been considered to find out a substitution to chemical synthesis. The quality and quantity of hexane extract from Anthemis coelopoda Boiss. (Family Compositae) roots and stems were analyzed by GC and GC/MS. The anti-bacterial activities of the chloroform extract of Anthemis coelopoda Boiss. roots and stems were evaluated by well diffusion method and disc diffusion method against four bacterial strains including: Staphylococcus aureus, Bacillus subtilis, Escherichia coli and Salmonella typhi. Finally minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) values by microdilution method were determined. The yields of the roots and stems on dry weight basis were 1%. Twenty-two components in roots and stems (95%) were identified. The major components including: Ascorbic acid 2, 6-dihexadecanoate (32.1%), 1, 2-Benzenedicarboxylic acid, bis (2-methylpropyl) ester (14.8%) and Trioctylamine (6.08%). Maximum inhibition zone (12 mm) of the extract was obtained against Staphylococcus aureus and Bacillus subtilis, at concentration of 6mg/ml and the best results of MIC and MBC were obtained for Bacillus subtilis at the concentration of 0.187 mg/ml and 0.375 mg/ml respectively. This study showed that Anthemis coelopoda Boiss. can be considered a natural antibacterial source.

Keywords: Anthemis coelopoda Boiss. var. coelopoda, Essential oils, Chemical composition, Antimicrobial activity.


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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing