EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

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 ISSN 2394-3211

Impact Factor: 6.222

 ICV - 79.57

Abstract

EFFECTS OF CO-ADMINISTRATION OF DEXAMETHASONE AND DICLOFENAC SODIUM ON THE POST-OPERATIVE OUTCOMES FOLLOWING MANDIBULAR THIRD MOLAR SURGERY UNDER LOCAL ANAESTHESIA

*Abd Allah Ibrahim Abd Alrahman Mudawi and M. A. Higzi

ABSTRACT

Background: The apparent interactions between the mechanisms of action of non-steroidal anti-inflammatory drugs (NSAIDS) and steroids imply that co-therapy may provide beneficial inflammatory and pain relief in the absence of side effects. The aim of the study was to compare the effect of co-administered dexamethasone and diclofenac sodium (diclofenac Na) with diclofenac Na alone on the postoperative pain, swelling and trismus after surgical removal of mandibular third molars. Patients and Methods: A prospective randomized double-blind study was conducted at the Department of Oral and Maxillofacial Surgery, minor surgery clinic at Khartoum Teaching Dental Hospital, Sudan. A total of 120 patients were randomly allocated to three treatment groups; dexamethasone (8mg IV preoperative) and diclofenac Na (75 mg IM preoperatively) group, diclofenac Na alone group (75mg IM preoperatively) and the third group as a control group without medication. The overall analgesic effectiveness of the drug combinations was assessed postoperatively by determination of pain intensity using a visual analogue scale. Facial swelling was measured using a tape measure placed from tragus to gonion to tragus, while interincisal mouth-opening of patients was measured using a metallic ruler preoperatively and post-operatively. Results: Co-administration of dexamethasone and diclofenac Na was significantly superior to Diclofenac Na alone for the relief of pain (P < 0.05) and facial swelling (P < 0.05). However, there was no significant difference for trismus relief between the two medication protocols (P > 0.05). Conclusion: This study demonstrate enhanced effects of co-administered dexamethasone and diclofenac Na on short-term post-operative pain and swelling, compared to diclofenac sodium alone in mandibular third molar surgery.

Keywords: diclofenac Na, 8mg IV preoperayive, 75mg IM preoperatively.


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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing