CARDIOPROTECTION OF AN INDIAN MEDICINAL HERB BY ASSESSING MITOCHONDRIAL AND LYSOSOMAL MARKER ENZYMES
*R. Savitha and U. Saraswathi
This study was carried out to examine the effect of Millingtonia hortensis against myocardial infarction(MI) induced by isoproterenol in rat model. Isoproterenol induced rats (20mg/100g bwt, subcutaneously) showed a significant decrease in the activities of heart mitochondrial enzymes (Malate dehydrogenase, Succinate dehydrogenase and α-keto glutarate dehydrogenase). The activities of lysosomal enzymes (β-NAG, Cathepsin-D and ACP) were found to be increased in ISO induced rats. Pretreatment with Silver nanoparticles (AgNPs) synthesized from Millingtonia hortensis significantly increased the activities of mitochondrial enzymes and decreased the activities of lysosomal enzymes in the heart tissue of ISO induced rats. Plant alone treated rats showed normal effect as that of control rats. This study showed that Millingtonia hortensis protects the heart against ISO induced MI by altering mitochondrial and lysosomal enzymes.
Keywords: Myocardial infarction, isoproterenol, mitochondrial enzymes, lysosomal enzymes, cardioprotection.
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