EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

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 ISSN 2394-3211

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Abstract

AUTOANTIBODIES DIABETES AND MICRONUTRIENTS IN TYPE 1 DIABETICS AND SIBLINGS OF ABIDJAN DISTRICT, IVORY COAST.

Chiayé Claire Antoinette Yapo-Crezoit*, Aïssé Florence Judith Trébissou1, Francis Adou Yapo, Sana Khlif, Amina Lahyani, Koumba Agbo-Soumahoro, Fatma MaKni Ayedi, Hatem Masmoudi, Joseph Allico Djaman, Mireille Dosso

ABSTRACT

Context: the presence of diabetes autoantibodies has been reported as a factor of predisposition of diabetes in siblings of type 1 diabetics. Objective: Search autoantibodies of diabetes anti-ICA, anti-GAD, anti-IA2 in type 1 diabetics and their siblings of district of Abidjan, Ivory Coast, associated with the dosage of micronutrients such as phosphorus, magnesium and calcium. Materials and methods: The study population consisted of 49 people, including 19 type 1 diabetics (T1D) and 30 siblings whose first degree of the blood was taken. T1D were recruited to University Hospital center (U.H.C) of Yopougon and Treichville and two NGOs. Serum obtained allowed the determination of anti-islet cell autoantibodies (anti-ICA) detected by the immunofluorescence method on monkey pancreas, anti-glutamic acid decarboxylase autoantibodies (anti-GAD) and anti- phosphatase IA2 detected by ELISA. The dosage of phosphorus, magnesium and calcium was made by the cobas 6000 Roche/Hitachi. Results: Anti-ICA was positive to 5.26% in T1D and absent in siblings, anti-GAD were positive in the T1D to 57.89% and 3.33% for the siblings. The anti-IA2 was positive in the T1D to 47.36% and 16.66% for siblings. The anti-ICA-GAD-IA2 combination was present in 5.26% of T1D and absent in the siblings. The GAD-IA2 combination was present in 31.57% of T1D and 3.33% among siblings. The average phosphorus in T1D was 1.86±1.06 mmol/L versus 2.39±1.51mmol/L in the siblings; twice higher than normal values. Conclusion: Autoantibodies diabetes in siblings is a marker for the imminence of autoimmune diabetes. Phosphorus is an important marker for the detection and follow up T1D.

Keywords: diabetes autoantibodies, phosphorus, magnesium, calcium, Type 1 diabetes.


[Full Text Article]

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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing Scholar Article Journal Index (SAJI) International Scientific Indexing ( ISI )