EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

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 ISSN 2394-3211

Impact Factor: 6.222

 ICV - 79.57

Abstract

MIMUSOPS ELENGI BARK AND FRUITS EXTRACTS AS POTENTIAL FREE RADICAL SCAVENGING AGENTS.

Priti S. Patil, Pratima A. Tatke* and Satish Y. Gabhe

ABSTRACT

Mimusops elengi (ME) Linn (Sapotaceae) commonly known as Bakul, is used as tonic, febrifuge, as gargle for odontopathy, inflammation, bleeding gums and healing of ulcers. Mimusops elengi is a rich source of tannin, saponin, alkaloids and glycosides which may be responsible for its therapeutic benefits. Aim of the present study was to evaluate antioxidant and free radical scavenging activity of various extracts of Bakul bark and fruits. Chloroform, acetone methanol and aqueous extracts of Bakul bark and fruits were prepared and evaluated for presence of phenolics and flavonoids. Extracts showing maximum phenolic content expressed as mg of GAE/g of dry extract and flavonoid content expressed as mg of RE/g of dry extract were further selected for various in vitro free radicals scavenging assays using DPPH scavenging, ABTS, peroxynitrite radicals, xanthine oxidase inhibition (XOI), superoxide scavenging and lipid peroxidation assay. Methanol and acetone extract of Bakul bark were found to contain higher amount of total phenolics. Presence of both these constituents in Bakul bark was highest in methanol extract followed by acetone extract, aqueous extract and least in chloroform extract. Acetone extract of Bakul fruits alone showed considerable amounts of these constituents as compared to other fruit extracts. The methanol extract of Bakul bark showed lowest IC50 values than acetone extract when evaluated by DPPH, ABTS, peroxynitrite inhibition, xanthine oxidase inhibition, superoxide scavenging and lipid peroxidation inhibition methods indicating good free radical scavenging activity. Acetone extract showed least free radicals scavenging activities with very high IC50 values against these free radicals.

Keywords: Mimusops elengi, DPPH, ABTS, total phenolics, flavonoids, rutin.


[Full Text Article]

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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing Scholar Article Journal Index (SAJI) International Scientific Indexing ( ISI )