EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

European Journal of Pharmaceutical and Medical Research (EJPMR) has indexed with various reputed international bodies like : Google Scholar , Indian Science Publications , InfoBase Index (In Process) , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , International Society for Research activity (ISRA) , Scientific Indexing Services (SIS) , Polish Scholarly Bibliography , Global Impact Factor (GIF) (Under Process) , Universal Impact Factor , International Scientific Indexing (ISI), UAE  , Index Copernicus , CAS (A Division of American Chemical Society) USA (Under Process) , Directory of Open Access Journal (DOAJ, Sweden, in process) , UDLedge Science Citation Index , CiteFactor , Directory Of Research Journal Indexing (DRJI) , Indian citation Index (ICI) , Journal Index (JI, Under Process) , Directory of abstract indexing for Journals (DAIJ) , Open Access Journals (Under Process) , Impact Factor Services For International Journals (IFSIJ) , Cosmos Impact Factor , Jour Informatics (Under Process) , Eurasian Scientific Journal Index (ESJI) , International Innovative Journal Impact Factor (IIJIF) , Science Library Index, Dubai, United Arab Emirates , Pubmed Database [NLM ID: 101669306] (Under Process) , IP Indexing (IP Value 2.40) , Web of Science Group (Under Process) , Directory of Research Journals Indexing , Scholar Article Journal Index (SAJI) , International Scientific Indexing ( ISI ) , 

 ISSN 2394-3211

Impact Factor: 6.222

 ICV - 79.57

Abstract

EVALUATION OF OXIDANT AND ENZYMATIC ANTIOXIDANT STATUS IN ASYMPTOMATIC SUBJECTS WITH HIV-1.

Adeoti Mansour Franck*1, Camara-Cisse Massara, Monteomo Gnate Francois, Koffi Gervais, Kolia Innocent, Djaman Allico Joseph and Dosso Mireille

ABSTRACT

Chronic viral infection with HIV is characterized by progressive and irreversible destruction of CD4 lymphocytes causing oxidative stress and antioxidant reaction. This study aimed to evaluate the immune responses, the balance between oxidant status and antioxidant capacity after in the Acquired Immunodeficiency Syndrome. The authors conducted a prospective study of 60 subjects aged 18 to 65 both sexes, including 30 people with VIH1et 30 healthy control subjects HIV-. In these patients and witnesses, it was made HIV status with an Elisa test and discriminative test (Immunocomb II HIV 1 & 2 BiSpot / PBS Orgenics) and counts as lymphocyte subsets (CD4+ and T-CD8+) is performed by the direct immunofluorescence technique. GPx was assayed by Elisa, SOD and catalase using the PLC Cobas Mira® (Roche Diagnostics) using Randox reagents. There was a significant reduction (p <0.05) in the number of CD4 cells (373.13 ± 69.90 vs 750 ± 30) and CD8 (759.28 ± 131.58 versus 1450 ± 46) patients HIV-1 compared to control subjects. However, a significant increase (p<0.05) markers peroxidation, TBARS (0.99 ± 0.26 versus 3.32 ± 0.40 nmol/MDA) and proteins, OAPP (39, 49 ± 21.20 versus 62.28 ± 13.70 μmol) which reflect an important oxidative stress. The low concentrations significantly (p <0.05) of GPx (40 ± 11 versus 82 ± 15 IU/gHb), SOD (1095 ± 20 vs 1313 ± 41 IU/gHb) and catalase (125 ± 18 versus 210 ± 13 IU/gHb) respectively related to chronic oxidative stress, are more pronounced among the HIV-1 patients. Conclusion: Considering the fall in activity of GPx, SOD and catalase in subjects with HIV-1 infection, they are exposed to oxidative stress and long term consequences.

Keywords: TBARS, OAPP, Superoxide dismutase, Glutathione peroxidase, Catalase, HIV.


[Full Text Article]

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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing Scholar Article Journal Index (SAJI) International Scientific Indexing ( ISI )