EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

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 ISSN 2394-3211

Impact Factor: 7.065

 ICV - 79.57

Abstract

STUDY OF CLINICAL AND LABORATORY PROFILE OF DENGUE FEVER PATIENTS

Spoorti Vulavala*, Yugandhar Reddy and Prabhakar Kamarthy

ABSTRACT

Objective: Dengue fever is one of the most common arboviral mediated outbreaks reported with increased prevalence year after year with considerable morbidity and mortality. This study was designed to assess the clinical and biochemical parameters of dengue fever patients. Methods: Prospective observational study was undertaken among adult patients in a rural tertiary care hospital. One fifty-five patients were studied and analysed. All patients who were NS1 antigen/IgM dengue positive were included in the study. Clinical features, haematological and biochemical parameters were noted. Results: Of the 155 patients studied, Majority of the patients were in 18-40 age group (60.32%) and were predominantly males (70.97%). Fever was present in all patient, followed by myalgia (94.83%), headache (90.96%). Thrombocytopenia(<50,000/cumm) at presentation was seen in 78.06% of cases. Leucopenia was noticed in 34.19% of cases. Raised liver serum transaminases were noted in 61.93% of patients out of which SGOT was elevated in 72.67% and SGPT in 27.33% of patients. Raised haematocrit (>45%) was noted in 23.22% of patients at presentation. Mortality rate was 1.29%. Conclusion: We conclude that dengue infection, which possesses serious public health problem, can be diagnosed early with the help of clinical features like retro orbital pain, myalgia, bleeding manifestations, thrombocytopenia, SGOT greater than SGPT that is supported by detection of NS1 antigen, IgG and IgM antibodies. Platelet transfusions have little role in management of dengue patients.

Keywords: Dengue fever, thrombocytopenia, serum transaminases.


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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing Scholar Article Journal Index (SAJI) International Scientific Indexing ( ISI ) Scope Database Academia