N-(4-(BENZIMIDAZOLE-2-YL) PHENYL) SULFONAMIDES BASED ON ACID / N'-(1H-BENZIMIDAZOL-2-YL) PHENYL HYDRAZIDO SULFONAMIDE BENZIMIDAZOLE DERIVATIVES: DESIGN, SYNTHESIS AND BIOLOGICAL EVALUATION
Nisha Devi, Saurabh, Deepika Choudhary and Sukhbir Lal Khokra*
A series of 2-(4-aminophenyl)benzimidazole (2a) based acid / 2-hydrazinobenzimidazole (2b) with the help of hydrazine hydrate which were then reacted with substituted sulfonyl chloride (4a-4f) and mixture of acetic anhydride, pyridine N-(4-(benzimidazole-2-yl)phenyl) sulfonamides, N'-(1H-benzimidazol-2-yl)phenyl hydrazido sulfonamides (5a-5l), respectively. The newly synthesized compounds were screened for their in-vitro biological activities including antimicrobial, and antioxidant activity. The Acetyl-CoA carboxylase (ACCase) inhibitor behavior of synthesized compounds was pre-assed via automated docking studies. Finally the whole effort leads to total 10 most promising analogues (5a, 5b, 5c, 5d, 5e, 5f, 5i, 5j, 5k, and 5l) which can be explored further as a template to design more potential agents against ACCase inhibitors.
Keywords: Benzimidazole, Acetyl-CoA carboxylase inhibitors, docking studies, antimicrobial, antioxidant activity.
[Full Text Article]