EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

European Journal of Pharmaceutical and Medical Research (EJPMR) has indexed with various reputed international bodies like : Google Scholar , Indian Science Publications , InfoBase Index (In Process) , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , International Society for Research activity (ISRA) , Scientific Indexing Services (SIS) , Polish Scholarly Bibliography , Global Impact Factor (GIF) (Under Process) , Universal Impact Factor , International Scientific Indexing (ISI), UAE  , Index Copernicus , CAS (A Division of American Chemical Society) USA (Under Process) , Directory of Open Access Journal (DOAJ, Sweden, in process) , UDLedge Science Citation Index , CiteFactor , Directory Of Research Journal Indexing (DRJI) , Indian citation Index (ICI) , Journal Index (JI, Under Process) , Directory of abstract indexing for Journals (DAIJ) , Open Access Journals (Under Process) , Impact Factor Services For International Journals (IFSIJ) , Cosmos Impact Factor , Jour Informatics (Under Process) , Eurasian Scientific Journal Index (ESJI) , International Innovative Journal Impact Factor (IIJIF) , Science Library Index, Dubai, United Arab Emirates , Pubmed Database [NLM ID: 101669306] (Under Process) , IP Indexing (IP Value 2.40) , Web of Science Group (Under Process) , Directory of Research Journals Indexing , Scholar Article Journal Index (SAJI) , International Scientific Indexing ( ISI ) , 

 ISSN 2394-3211

Impact Factor: 6.222

 ICV - 79.57

Abstract

N-(4-(BENZIMIDAZOLE-2-YL) PHENYL) SULFONAMIDES BASED ON ACID / N'-(1H-BENZIMIDAZOL-2-YL) PHENYL HYDRAZIDO SULFONAMIDE BENZIMIDAZOLE DERIVATIVES: DESIGN, SYNTHESIS AND BIOLOGICAL EVALUATION

Nisha Devi, Saurabh, Deepika Choudhary and Sukhbir Lal Khokra*

ABSTRACT

A series of 2-(4-aminophenyl)benzimidazole (2a) based acid / 2-hydrazinobenzimidazole (2b) with the help of hydrazine hydrate which were then reacted with substituted sulfonyl chloride (4a-4f) and mixture of acetic anhydride, pyridine N-(4-(benzimidazole-2-yl)phenyl) sulfonamides, N'-(1H-benzimidazol-2-yl)phenyl hydrazido sulfonamides (5a-5l), respectively. The newly synthesized compounds were screened for their in-vitro biological activities including antimicrobial, and antioxidant activity. The Acetyl-CoA carboxylase (ACCase) inhibitor behavior of synthesized compounds was pre-assed via automated docking studies. Finally the whole effort leads to total 10 most promising analogues (5a, 5b, 5c, 5d, 5e, 5f, 5i, 5j, 5k, and 5l) which can be explored further as a template to design more potential agents against ACCase inhibitors.

Keywords: Benzimidazole, Acetyl-CoA carboxylase inhibitors, docking studies, antimicrobial, antioxidant activity.


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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing Scholar Article Journal Index (SAJI) International Scientific Indexing ( ISI )