FORMULATION AND EVALUATION OF CONTROLLED POROSITY OSMOTIC TABLET OF METOPROLOL SUCCINATE

Hitesh Jain*, Falguni Sharma, Vinish Sharma, Jilika Shah and Umesh Upadhyay

ABSTRACT

Objectives: Metoprolol Succinate is mainly used to treat hypertension. It has a short elimination half- life and rapidly absorbed in GIT. Conventional tablets of Metoprolol succinate require multiple dosing with resulting inconvenience to the hypertensive patient and the possibility of reduced patient compliance. Experimental Work: Core tablets for drug were prepared by direct compression technique using mannitol, fructose, KCl as osmogens and Avicel PH101 as direct compressible diluents. The prepared core tablets were coated by coating agent cellulose acetate (2%w/v) with PEG400 and PEG 6000as water soluble pore former and dibutyl-pthalate as plasticizer. The formulations were evaluated for their pre compression and post compression characterizations. Results and discussion: The present study confirmed that the drug release depends on the % weight gain of tablet and it is inversely proportional to membrane weight gain. The combination of two osmogens shows better drug release as compared to individual.

Keywords: Metoprolol succinate, Hypertension, controlled porosity, Osmogen.