EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

European Journal of Pharmaceutical and Medical Research (EJPMR) has indexed with various reputed international bodies like : Google Scholar , Indian Science Publications , InfoBase Index (In Process) , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , International Society for Research activity (ISRA) , Scientific Indexing Services (SIS) , Polish Scholarly Bibliography , Global Impact Factor (GIF) (Under Process) , Universal Impact Factor , International Scientific Indexing (ISI), UAE  , Index Copernicus , CAS (A Division of American Chemical Society) USA (Under Process) , Directory of Open Access Journal (DOAJ, Sweden, in process) , UDLedge Science Citation Index , CiteFactor , Directory Of Research Journal Indexing (DRJI) , Indian citation Index (ICI) , Journal Index (JI, Under Process) , Directory of abstract indexing for Journals (DAIJ) , Open Access Journals (Under Process) , Impact Factor Services For International Journals (IFSIJ) , Cosmos Impact Factor , Jour Informatics (Under Process) , Eurasian Scientific Journal Index (ESJI) , International Innovative Journal Impact Factor (IIJIF) , Science Library Index, Dubai, United Arab Emirates , Pubmed Database [NLM ID: 101669306] (Under Process) , IP Indexing (IP Value 2.40) , Web of Science Group (Under Process) , Directory of Research Journals Indexing , Scholar Article Journal Index (SAJI) , International Scientific Indexing ( ISI ) , 

 ISSN 2394-3211

Impact Factor: 6.222

 ICV - 79.57

Abstract

ANALYSIS OF LINAGLIPTIN IN TABLET DOSAGE FORM BY UV SPECTROSCOPY METHOD, ITS DERIVATIVES AND DIFFERENCE SPECTRA

R.K. Sangeetha* and T. Subashri

ABSTRACT

A simple and rapid method of analysis of linagliptin has been established by validated UV spectroscopy method, difference spectroscopy and first order & second order derivative spectra after the identification of drug with its IR spectra interpretation. The UV spectroscopic method was validated according to ICH guidelines for its Linearity, Intraday precision, Interday precision, Accuracy, Limit of Detection and Limit of Quantification. The solvent selected was methanol and the maximum absorbance was found at 228 nm. The linearity range was found between 5-40 mcg/ml with a correlation coefficient of 0.9985 and the slope of the curve was found to be 0.0406. The precision values were found to be below 1 showing its repeatability and reproducibility of the method. The accuracy of method was found by the analysis of formulation and recovery studies at 100% level with % RSD value of 0.5472. The difference spectroscopy method was performed with 0.1 M HCl and 0.1 M NaOH. The difference absorbance was used to calculate the assay value and was found to be 95%. The first order spectra and the second order spectra was obtained from the zero order spectrum of standard drug linear range of 10-40 mcg/ml at the wavelength of 238 nm and 228 nm respectively were selected for the calibration graph. The correlation coefficient was found to be 0.9982 and 1.0 for first order and second order spectra. The method adopted for the analysis of linagliptin are economical, reliable, simple and accurate. This metho can be used for further studies of linagliptin.

Keywords: The method adopted for the analysis of linagliptin are linagliptin.


[Full Text Article]

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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing Scholar Article Journal Index (SAJI) International Scientific Indexing ( ISI )