OUTCOME AND DETERMINANTS OF OUTCOME OF STATUS EPILEPTICUS AT DISCHARGE IN INDIAN CHILDREN
Mishra Ashwani Kumar* and Srivastava Kavita
Background: Status epilepticus is a medical emergency that requires rapid and aggressive treatment to prevent systemic complications and neurological damage. Few Indian studies on outcome of pediatric SE are available. Objective: To evaluate the outcome and determinants of outcome of status epilepticus in children at discharge. Materials and methods: A cross-sectional hospital based study was undertaken of cases with status epilepticus admitted to the pediatric ward or PICU in a tertiary care center between September 2013 to March 2015. They were studied for their demographics, clinical presentation and evaluated with regards to development of epilepsy, focal motor deficit and mortality at discharge. Results: Of the 39 subjects enrolled for the study, 5 (12.8%) died. 64% subjects were less than 5 years of age and 61.5% were males. 15.4% had a family history of epilepsy. 25.6% subjects had a seizure duration of > 1 hour. 74% had symptomatic etiology, 10% had idiopathic etiology and for the rest etiology was unknown. All 21 subjects who showed delayed development on admission had poor outcomes. There was a significant positive correlation between (p=0.037) between the presence of prenatal insult either in terms of HIE, hypoglycemia or neonatal seizures and poor outcomes on discharge. Conclusion: Children who had prior developmental delay orperinatal insult had significantly worse outcomes in terms of high seizure frequency with moderate to severe cognitive or motor delay.
Keywords: Status epilepticus, outcome, determinants, discharge.
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