EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

European Journal of Pharmaceutical and Medical Research (EJPMR) has indexed with various reputed international bodies like : Google Scholar , Indian Science Publications , InfoBase Index (In Process) , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , International Society for Research activity (ISRA) , Scientific Indexing Services (SIS) , Polish Scholarly Bibliography , Global Impact Factor (GIF) (Under Process) , Universal Impact Factor , International Scientific Indexing (ISI), UAE  , Index Copernicus , CAS (A Division of American Chemical Society) USA (Under Process) , Directory of Open Access Journal (DOAJ, Sweden, in process) , UDLedge Science Citation Index , CiteFactor , Directory Of Research Journal Indexing (DRJI) , Indian citation Index (ICI) , Journal Index (JI, Under Process) , Directory of abstract indexing for Journals (DAIJ) , Open Access Journals (Under Process) , Impact Factor Services For International Journals (IFSIJ) , Cosmos Impact Factor , Jour Informatics (Under Process) , Eurasian Scientific Journal Index (ESJI) , International Innovative Journal Impact Factor (IIJIF) , Science Library Index, Dubai, United Arab Emirates , Pubmed Database [NLM ID: 101669306] (Under Process) , IP Indexing (IP Value 2.40) , Web of Science Group (Under Process) , Directory of Research Journals Indexing , Scholar Article Journal Index (SAJI) , International Scientific Indexing ( ISI ) , 

 ISSN 2394-3211

Impact Factor: 6.222

 ICV - 79.57

Abstract

EVALUATION OF ANTIHYPERTENSIVE ACTIVITY OF CUCURBITA MAXIMA

Dr. C. Madhavi Latha* and Yalla Reddy Kolavali

ABSTRACT

Cucurbita maxima, belongs to family Cucurbitaceae, is commonly known as pumpkin. Several literature reports suggest it to be antidiabetic, antihypertensive, anticancer, immunomodulators, antibacterial and antihyperlipidaemic. The present study was conducted to investigate the effect of the methanolic extract Cucurbita maxima of on blood pressure of both normotensive and hypertensive (egg- feed and glucose- induced) rats. The effect of the extract on systolic, diastolic, mean blood pressures and heart rate were evaluated by using non-invasive blood pressure measurement apparatus (NIBP). The extract at doses of 200 and 400 mg/kg (p.o) exhibited a significant decrease in blood pressure and heart rate of normotensive rats. While at the dose of 200mg/kg (p.o) it produces less significant effect than 400 mg/kg (p.o). The 400mg/kg of the extract produces a highly significant effect was selected for antihypertensive effect in egg feed and glucose treated hypertensive rats. A significant antihypertensive was observed at 400 mg/kg (p.o) in both hypertensive models. In addition, a non-significant decrease in ALT, AST, and ALP but significant decrease in total cholesterol, triglycerides, LDL and increase in HDL levels were observed in the serum of the extract treated animals. The methanolic extract of Cucurbita maxima possesses safer active principles which exert both hypotensive and antihypertensive effects in normal and hypertensive animal models respectively.

Keywords: Cucurbita maxima, Immunomodulatory, Hypertensive, Glucose.


[Full Text Article]

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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing Scholar Article Journal Index (SAJI) International Scientific Indexing ( ISI )