ANTICONVULSANT ACTIVITY OF BORASSUS FLABELLIFER LEAF EXTRACTS

Saravanan Kaliyaperumal*, Pushpesh Kumar Mishra and Girendra Kumar Gautam

ABSTRACT

To determine the anticonvulsant activity of leaf extract of Borassus flabellifer Linn. in Wistar albino rats and in order to verify the traditional use of the plant in the treatment of epilepsy. The Maximal Electro Shock Seizure (MES) and Pentylenetetrazole (PTZ) were used for assessing the anticonvulsant activity of alcoholic and aqueous leaf extracts of Borassus flabellifer on wistar albino rats. The acute toxicity study was conducted as per guidelines set by OECD, and no adverse effects or mortality were detected up to 4g/kg,p.o.,based on the results obtained from the study the dose for anticonvulsant activity was fixed to be 100mg,200mg,400mg/kg b.w.,for dose dependent study. The alcoholic extract (400mg) of Borassus flabellifer had shown potent anticonvulsant activity than other extracts when compare to control group and the phenytoin and diazepam treated animals shown 100 percent protection against convulsant.The result from the study indicate that the 400mg of alcoholic leaf extract of Borassus flabellifer Linn. may be beneficial for anticonvulsant activity.

Keywords: Borassus flabellifer, Anticonvulsant activity, MES, PTZ.