EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

European Journal of Pharmaceutical and Medical Research (EJPMR) has indexed with various reputed international bodies like : Google Scholar , Indian Science Publications , InfoBase Index (In Process) , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , International Society for Research activity (ISRA) , Scientific Indexing Services (SIS) , Polish Scholarly Bibliography , Global Impact Factor (GIF) (Under Process) , Universal Impact Factor , International Scientific Indexing (ISI), UAE  , Index Copernicus , CAS (A Division of American Chemical Society) USA (Under Process) , Directory of Open Access Journal (DOAJ, Sweden, in process) , UDLedge Science Citation Index , CiteFactor , Directory Of Research Journal Indexing (DRJI) , Indian citation Index (ICI) , Journal Index (JI, Under Process) , Directory of abstract indexing for Journals (DAIJ) , Open Access Journals (Under Process) , Impact Factor Services For International Journals (IFSIJ) , Cosmos Impact Factor , Jour Informatics (Under Process) , Eurasian Scientific Journal Index (ESJI) , International Innovative Journal Impact Factor (IIJIF) , Science Library Index, Dubai, United Arab Emirates , Pubmed Database [NLM ID: 101669306] (Under Process) , IP Indexing (IP Value 2.40) , Web of Science Group (Under Process) , Directory of Research Journals Indexing , Scholar Article Journal Index (SAJI) , International Scientific Indexing ( ISI ) , 

 ISSN 2394-3211

Impact Factor: 6.222

 ICV - 79.57

Abstract

PHARMACOLOGICAL EVALUATION OF METHOTREXATE INDUCED HEPATOTOXICITY IN WISTAR RATS

Kumari Shalini and Kumari Savita*

ABSTRACT

Objective: Drugs and chemicals are considered as one of the major causes for hepatotoxicity, inducing direct damage through multiple pathways including oxidative stress. Amlycure DS is a polyherbal hepatoprotective formulation indicated as liver protective. The present study was aimed to investigate the protective effect of Amlycure DS in methotrexate induced hepatotoxicity in wistar albino rats. Method: 30 rats of either sex were divided into 5 groups. Group-I serves as normal control receiving normal standard pellet diet and water ad libitum. Group-II serves as toxic control with methotrexate (100μg/kg i.p.) once daily for 40 days. Group-III serves as standard control receiving silymarin(63mg/kg) orally, daily for 40 days. Group IV and V received Amlycure DS at doses 1406 and 5608 mg/kg orally respectively for 40 days. At the end of 40 days methotrexate injection induces significant oxidative stress with rise in serum ALT, serum AST, BIT, BID, AST where as levels of serum albumin and serum protein were reduced, in addition Antioxidant glutathione, Catalase value was reduced. Treatment of rats with different doses of Amlycure DS (1406 and 5608 mg/kg) significantly (P<0.05) ameliorated the alteration induced by methotrexate in oxidative stress and serum biochemical analysis. Conclusion: Based on these results, we conclude that Amlycure DS protects liver from oxidative damage induced by methotrexate.

Keywords: polyherbal hepatoprotective, Amlycure DS.


[Full Text Article]

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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing Scholar Article Journal Index (SAJI) International Scientific Indexing ( ISI )