EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

European Journal of Pharmaceutical and Medical Research (EJPMR) has indexed with various reputed international bodies like : Google Scholar , Indian Science Publications , InfoBase Index (In Process) , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , International Society for Research activity (ISRA) , Scientific Indexing Services (SIS) , Polish Scholarly Bibliography , Global Impact Factor (GIF) (Under Process) , Universal Impact Factor , International Scientific Indexing (ISI), UAE  , Index Copernicus , CAS (A Division of American Chemical Society) USA (Under Process) , Directory of Open Access Journal (DOAJ, Sweden, in process) , UDLedge Science Citation Index , CiteFactor , Directory Of Research Journal Indexing (DRJI) , Indian citation Index (ICI) , Journal Index (JI, Under Process) , Directory of abstract indexing for Journals (DAIJ) , Open Access Journals (Under Process) , Impact Factor Services For International Journals (IFSIJ) , Cosmos Impact Factor , Jour Informatics (Under Process) , Eurasian Scientific Journal Index (ESJI) , International Innovative Journal Impact Factor (IIJIF) , Science Library Index, Dubai, United Arab Emirates , Pubmed Database [NLM ID: 101669306] (Under Process) , IP Indexing (IP Value 2.40) , Web of Science Group (Under Process) , Directory of Research Journals Indexing , Scholar Article Journal Index (SAJI) , International Scientific Indexing ( ISI ) , 

 ISSN 2394-3211

Impact Factor: 6.222

 ICV - 79.57

Abstract

EFFECT OF MYO INOSITOL VERSUS METFORMIN ON QUALITY OF LIFE IN POLYCYSTIC OVARIAN SYNDROME IN WOMEN

Jyoti Kaushal, *Jyoti Nehra, Savita Rani Singhal and Veena Singh Ghalaut

ABSTRACT

Introduction: In polycystic ovary syndrome (PCOS), changes in physical appearance i.e. weight gain and body hair, menstrual disturbances and infertility result in psychological distress and reduced quality-of-life. Metformin and Myo-inositol being insulin sensitizers improve biochemical, clinical and reproductive parameters in PCOS in women.This study was done to compare the quality of life of Myo-inositol versus Metformin in PCOS in women. Material & Methods: A prospective, open labeled, randomized, comparative, clinical study was conducted on 60 patients. The patients were randomly divided in two groups of 30 each to receive either of the following two treatments: Group A: Tab Myo-inositol 1g twice daily. Group B: Tab Metformin 500mg thrice daily for 24 weeks. QOL assessment was done by HRQOL questionnaire by Cronin et al. at week 0, 12 and 24. Five domains i.e. emotions, body hair, weight, infertility and menstrual problems were assessed. Results: There was significant improvement in QOL parameters, in all the five domains in both the groups over a period of 24 weeks. However, on comparing both the groups at 24 weeks, there was no significant difference in all the five domains. Conclusion: Metformin and Myo-inositol are used for the treatment of PCOS. These drugs improve insulin resistance, menstrual irregularities, hyperandrogenism and infertility. QOL which is reduced in PCOS, was assessed by the administration of both of these drugs. Although there was a definite improvement in QOL with both types of treatment in PCOS in women but on comparing both the groups no significant difference was observed.

Keywords: HRQOL, Metformin, PCOS, Myo-inositol, Insulin sensitizers.


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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing Scholar Article Journal Index (SAJI) International Scientific Indexing ( ISI )